Research - Syzygium cumini
Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats
Rachel Melo Ribeiro,1 Vicente Férrer Pinheiro Neto,2 Kllysmann Santos Ribeiro,1 Denilson Amorim Vieira,1 Iracelle Carvalho Abreu,1 Selma do Nascimento Silva,1 Maria do Socorro de Sousa Cartágenes,1 Sônia Maria de Farias Freire,1 Antonio Carlos Romão Borges,1 and Marilene Oliveira da Rocha Borges1
1Laboratory of Pharmacology, Department of Physiological Science, Federal University of Maranhão (UFMA), Avenida dos Portugueses 1966, Bacanga, 65080-805 São Luís, MA, Brazil
2Department of Veterinary Medicine, State University of Maranhão (UEMA), 65055-970 São Luís, MA, Brazil
This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract of Syzygium cuminileaves (HESC) in normotensive Wistar rats and in spontaneously hypertensive rats (SHR), as well as its in vitroeffect on the vascular reactivity of resistance arteries. The hypotensive effect caused by intravenous infusion of HESC (0.01–4.0 mg/kg) in anesthetized Wistar rats was dose-dependent and was partially inhibited by pretreatment with atropine sulfate. SHR received HESC (0.5 g/kg/day), orally, for 8 weeks and mean arterial pressure, heart rate, and vascular reactivity were evaluated. Daily oral administration of HESC resulted in a time-dependent blood pressure reduction in SHR, with a maximum reduction of 62%. In the endothelium-deprived superior mesenteric arteries rings the treatment with HESC reduced by 40% the maximum effect (Emax) of contraction induced by NE. The contractile response to calcium and NE of endothelium-deprived mesenteric rings isolated from untreated SHR was reduced in a concentration-dependent manner by HESC (0.1, 0.25, and 0.5 mg/mL). This study demonstrated that Syzygium cumini reduces the blood pressure and heart rate of SHR and that this antihypertensive effect is probably due to the inhibition of arterial tone and extracellular calcium influx.
Source : Journal Evidence Based Complementary and Alternative Medicine
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