Research - Rosa rugosa, Rosa canina
Rosehip Oil Promotes Excisional Wound Healing by Accelerating the Phenotypic Transition of Macrophages
Zhiyong Lei, Zhijian Cao, Zaiwang Yang, Mingzhang Ao, Wenwen Jin, Longjiang Yu
Poor wound healing is a major and global threat to public health. Efforts have been made to better understand the underlying mechanisms and develop effective remedies, though the advancements that have been made are still limited. As there are no effective and generally applicable therapies available for skin injuries and fibrosis, it is urgent to develop new drugs and therapies that facilitate wound healing and effectively improve scars. In this study, GC-MS analysis was performed to identify the chemical composition of rosehip oil. The excisional wound healing model and the carrageenan-induced paw edema method were respectively applied to evaluate the wound healing activity and anti-inflammatory activity of rosehip oil. Hematoxylin and eosin staining was used to assess the pathological changes of sections, and Sirius-red staining was performed to analyze the ratio of collagen I/III in wound tissues. Immunohistological staining for CD68, CCR7 (CD197), CD163, TGF-β1, and α-SMA was applied to determine the macrophage phenotypes transition (M1-to-M2) and demonstrate the scar-improving efficacy of rosehip oil on wound healing. Results showed that rosehip oil significantly promoted wound healing and effectively improved scars. This efficacy might be exerted by accelerating the macrophage phenotypes transition and inhibiting the process of epithelial-mesenchymal transition.
Source : Journal Planta Medica
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Effect of Rosa canina L. (Rose-hip) on cold during winter season in a middle-class population: A randomized, double-blinded, placebo-controlled trial
Kaj Winthera Lina Warholmb Joan Campbell-Toftec Kristian Marstrandd
The common cold has social and economic implications worldwide. This study aimed to test if a liquid standardised preparation, Hyben Vital, based on shells from Rose-hip (Rosa canina L.), reduces the incidence and symptoms of the common cold in Danish middle-class volunteers.
Volunteers (n = 120) were randomly allocated to daily treatments with either 2 g of liquid Rose-hip (RH) or placebo (P) for six months during winter. Primary effect variables: The frequency of colds and symptoms related to cold. Secondary effect variables: Evaluations from diaries of muscle stiffness and general well-being (numerical scales).
A number of 107 volunteers completed the trial and 31 out of 58 patients (53.4%) in the P group reported cold vs 24 out of 55 patients (43.6%) in the RH group; 18.4% reduction (p = 0.348). The numbers of volunteers reporting the different symptoms of cold in P-group vs RH-group were: Coughing: 23 vs 18, p < 0.422; Headache: 26 vs 17, p < 0.112; Muscle stiffness: 27 vs 15, p < 0.027 and Fatigue: 29 vs 20, p < 0.115. Muscle stiffness, evaluated over 6 month, fell from initial 2.40 ± 2.32 to 2.02 ± 2.15 in the RH group and from 2.37 ± 2.40 to 2.93 ± 2.50 in the P group, (p < 0.043, comparing groups). The delta improvement in general well-being was 0.21 ± 0.74 (p < 0.019) vs 0.12 ± 1.08 (p < 0.078) in the RH-and P group, respectively (p < 0.861, comparing groups).
Our data suggest that administration of liquid Rose-hip reduces the incidence of colds by 18% and lowers the number of patients reporting the different symptoms of cold.
Source : Journal Herbal Medicine
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The Serum Lipid Lowering Effect of Rugosa Rose Petal Extract Rich in Polyphenols in Adults with High Serum Triglyceride
Takashi YAMAGISHI1,2, Keiji TAKANO1,3, Sumio KONDO41
Harunire Bio Institute Ltd.2 Kitami Institute of Technology3 DRC Ltd.4 Medical Corporation Kenshou-kai Fukushima Health Care Center
Objective: Hypertriglyceridemia or elevated serum triglyceride (TG) is a leading risk factor for developing atherosclerotic cardio-vascular diseases. This clinical study was designed to test the potential of polyphenol-rich extract from Rosa rugosa petals (PE) for improving hypertriglyceridemia and other types of dyslipidemia.
Methods: An open-label clinical study was conducted on 19 male and female adult subjects with elevated serum TG (120–399mg/dL), who were intervened the study diet containing (in a daily dose) 200mg of PE once daily for sss4 weeks. The serum levels of TG and cholesterols were measured at baseline and week-4. The efficacy was evaluated by comparing the measurements at these two time points.
Results: A significant decrease (P<0.05) in serum TG, as well as in serum total cholesterol and non HDL-cholesterol, and a marginal-ly significant decrease (P=0.070) in serum LDL-cholesterol were observed, while serum HDL-cholesterol was virtually not changed. The study diet was well tolerated without any untoward side effect
.Conclusions: The PE-containing diet appears to have benefits in improving hypertriglyceridemia and hypercholesterolemia
Source : Japanese Journal of Complementary and Alternative Medicine
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