Research - Betulin / Betulinic Acid
Betulinic acid is a triterpene of natural origin isolated from various plants. It can be isolated from the methanolic extract of Quisqualis fructus , the dichloromethane-methanol extract of the twigs of Coussarea paniculata ,the dichloromethane-methanol (1:1 v/v) extract of Argentinean legume Caesalpinia paraguariensis , the methanolic extract of the leaves of Vitex negundo , twigs of Ilex macropoda , the ethanolic extract of the roots of Anemone raddeana , leaves and wood of Doliocarpusschottianus , ethanolic extract of Tovomita krukovii ,fruits of Chaenomeles lagenaria , methanol, hexane and ethyl acetate extracts of stem bark of Berlinia grandiflora, methanolic extract of the aerial parts of Vietnamese Orthosiphon stamineus , leaves of Eucalyptus camaldulensis , stem barks of Physocarpus intermedium and Tetracentron sinense , chloroform extract of barks of Syncarpa glomulifera , methanolic extract of leaves of Combretum quadrangulare , methyl ethylketone extract of Tetracera boiviniana, dichloromethane extract of stem bark of Brazilian medicinal plant Zizyphusjoazeiro , ethanolic extract of the root barks of theTanzanian tree Uapaca nidida , Ipomea pescaprae ,Ancistrocladus heyneanus , Diospyros leucomelas ,and from the leaves of Syzrgium claviforum 
Betulinic Acid and Its Derivatives: A Review on their Biological Properties
Perumal Yogeeswari* and Dharmarajan Sriram
Pharmacy Department, Birla Institute of Technology & Science, Pilani-333031, INDIA
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial,antimalarial, anti inflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990’s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms ofaction. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.
Source : Current Medicinal Chemistry
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