Research - Atractylodes lancea
Lipase Inhibition and Antiobesity Effect of Atractylodes lancea
Ping Jiao1, Julie Tseng-Crank1, Brandon Corneliusen1, Mesfin Yimam1, Mandee Hodges1, Mei Hong1,Catherine Maurseth1, Misun Oh2, Hyunjin Kim2, Min Chu1,2, Qi Jia1,2
Affiliations1Unigen USA, Seattle, WA, USA 2Unigen Korea, Cheonam Si, Chungnam, South Korea
Abstract
The ethanol extract o fAtractylodes lancea rhizome displayed significant lipase inhibition withan IC50value of 9.06μg/mL in a human pancreatic lipase assay from high-throughput screening. Bio-assay-guided isolation led to the identification of one new polyacetylene,syn-(5E,11E)-3-acetoxy-4-O-(3-methylbutanoyl)-1,5,11-tridecatriene-7,9-diyne-3,4-diol (7), along with six known compounds (1–6). The structure of compound 7 was determined based on the analysis of NMR and MS data. Among these seven lipase inhibitors,the major compound atractylodin (1) showed the highest lipase inhibitory activity (IC50=39.12μM). The antiobesity effect of the ethanol extract of Atractylodes lancea rhizome was evaluated in a high-fat diet-induced obesity mice model at daily dosages of 250mg/kg and 500mg/kg body weight for 4 weeks, and treatment with this extract demonstrated a moderate efficacy at the 500mg/kg dose level
Source : Planta Medica
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