Research - Anaemia
Positive Association of Vitamin E Supplementation with Hemoglobin Levels in Mildly Anemic Healthy Pakistani Adults
Tanveer JilaniRelated information
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
, Iqbal AzamRelated information
Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
, Bushra MoizRelated information
Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan
, Naseema MehboobaliRelated information
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
, and Mohammad Perwaiz Iqba
Abstract
Background: Hemoglobin levels slightly below the lower limit of normal are common in adults in the general population in developing countries. A few human studies have suggested the use of antioxidant vitamins in the correction of mild anemia. The objective of the present study was to investigate the association of vitamin E supplementation in mildly anemic healthy adults with post-supplemental blood hemoglobin levels in the general population of Karachi, Pakistan.
Method: In a single-blinded and placebo-controlled randomized trial, 124 mildly anemic subjects from the General Practitioners’ Clinics and personnel of the Aga Khan University were randomized into intervention (n = 82) and control (n = 42) group. In the intervention group, each subject was given vitamin E (400 mg) everyday for a period of three months, while control group subjects received a placebo. Eighty six subjects completed the trial. Fasting venous blood was collected at baseline and after three months of supplementation. Hemoglobin levels and serum/plasma concentrations of vitamin E, vitamin B12, folate, ferritin, serum transferrin receptor (sTfR), glucose, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, creatinine, total-antioxidant-status and erythropoietin were measured and analyzed using repeated measures ANOVA and multiple linear regression.
Results: The adjusted regression coefficients (β) and standard error [SE(β)] of the significant predictors of post-supplemental hemoglobin levels were serum concentration of vitamin E (0.983[0.095]), gender (- 0.656[0.244]), sTfR (- 0.06[0.02]) and baseline hemoglobin levels (0.768[0.077]).
Conclusion: The study showed a positive association between vitamin E supplementation and enhanced hemoglobin levels in mildly anemic adults.
Source : Intl Journal for Vitamin and Nutrition Research
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Acetate supplements speed up red blood cell production, anemia research shows
UT Southwestern Medical Center researchers seeking novel treatments for anemia found that giving acetate, the major component of household vinegar, to anemic mice stimulated the formation of new red blood cells. Currently, the hormone erythropoietin is administered to treat anemia, but this treatment carries with it side effects such as hypertension and thrombosis (blood clotting). The new research, which was performed in mice, suggests that acetate supplements could eventually be a suitable supplement or possibly even an alternative to administration of erythropoietin.
"Using rational interventions based on the mechanistic insights gleaned from our current studies, we may be able to treat acutely or chronically anemic patients with acetate supplements and thereby reduce the need for blood transfusions or erythropoietin therapy," said Dr. Joseph Garcia, Associate Professor of Internal Medicine at UT Southwestern, staff physician-scientist at the VA North Texas Health Care System, and senior author of the study, published in Nature Medicine.
Anemia is the most common blood disorder, affecting some 3.5 million people, including children and women of child-bearing age, as well as many elderly persons. It can have a significant impact on quality of life, leading to fatigue, weakness, and decreased immune function. People who are anemic produce insufficient red blood cells, which deliver oxygen to tissues throughout the body.
UT Southwestern researchers began their studies by identifying a critical pathway that controls the production of red blood cells in conditions of stress, such as low oxygen. Using genetically modified mice, researchers observed that low oxygen, a state known as hypoxia, stimulates the production of acetate.
Acetate, in turn, activates a molecular pathway that ultimately results in the production of red blood cells, or erythropoiesis, by triggering the production of the protein that stimulates this process, called erythropoietin.
"Our study shows that acetate functions as a biochemical 'flare,' linking changes in cell metabolism that occur during hypoxia with the activation of a selective stress signaling pathway," Dr. Garcia said.
Source : Science Daily
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Anti-inflammatory action of ginger: A critical review in anemia of inflammation and its future aspects
Subodh Kumar1*, Kiran Saxena2, Uday N. Singh1, Ravi Saxena2
1. Department of Biochemistry, Major S D Singh Medical College & Hospital, Fatehgarh (U.P.), India
2. Department of Biochemistry, Chirayu Medical College & Hospital, Bhopal (M.P.) India
Abstract: Anti-inflammatory action of ginger has been confirmed by various scientists, but there is very few review article published till date on inflammation associated diseases. Inflammation is mainly, culprit of anemia and inflammation associated disorder (like- Pulmonary diseases, Cardiovascular diseases, Diabetes Type-2, cancer, Arthritis, Alzheimer, Neurological diseases and Autoimmune diseases).Since Infection (bacterial/ viral), activate Nuclear factor –-κB, which is a major mediator of inflammation in most of the disease. Zinger has been established potent NF–ƙB inhibitory action via the suppression of pro-inflammatory cytokine, TNF-α and also provides a molecular link between the innate and adaptive immune system. This review takes the Zinger bioactive components, property, Chemical composition, Mechanism of action, function, side effects, current research and their potential application in modern medicine. The present study demonstrates that ginger showed broad spectrum action in which Anti-inflammatory action is one of them. So the present study concludes that ginger and its bioactive components have the potential for development of modern medicine in the treatment of anemia and various diseases in near future.
Source : International Journal of Herbal Medicine
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Antianaemic Potential of Swertia chirata on Phenylhydrazine Induced Reticulocytosis in Rats
Ashish Turaskar1*, Sachin More1, Rizwan Sheikh1, J. Gadhpayle2, Dr. S. L. Bhongade1, Vikas Shende3
1Manoharbhai Patel Institute of Pharmacy [B.Pharm.] Gondia [MS] India
2S. N. Mor College of Science, Tumsar, Bhandara [MS] India
3Sharadchandra Pawar College of Pharmacy, Ottur, Pune, [MS] India
Abstract
The antianemic potential of Swertia chirata extracts on phenylhydrazine induced anemia in rats was investigated. The ethanolic extract of Swertia chirata leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of this plant extracts at 200 mg/kg/day and 400 mg/kg/day, to the rats previously treated with phenylhydrazine, increased the concentration of haemoglobin, red blood cells number, haematocrit and reticulocytes rate.
Conclusion
The extracts of Swertia chirata leaves reversed anaemia induced by phenylhydrazine model of anaemia similar to those induced by parasite such as Plasmodium falciparum17. The vitamin and mineral constituents of the leaf appear most likely as the active ingredients responsible for the haematinic effect of Swertia chirata leaves. This result supports at least partially the traditional use of Swertia chirata in the treatment of anaemia.
Source : American Journal of Phytomedicine and Therapeutics
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