 
Am J Drug Alcohol Abuse report " Ibogaine was associated with substantive effects on opioid withdrawal symptoms and drug use in subjects for whom other treatments had been unsuccessful, and may provide a useful prototype for discovery and development of innovative pharmacotherapy of addiction."
The Journal of Integrative and Complementary Medicine report "Our systematic review revealed that Auricular Acupressure (AA) significantly improved pain, pressure pain thresholds, and disability in individuals with various chronic musculoskeletal pain conditions immediately post-treatment compared with sham treatment. Given the paucity of studies and inconsistent protocols, future RCTs are warranted to evaluate the effectiveness of AA in people with chronic musculoskeletal pain at a longer follow-up with detailed protocols, which allows researchers and clinicians to optimize AA intervention.
The Journal of Traditional Chinese Medical Sciences report "This study showed that Xiaoyaosan improved the behavioral symptoms of CIS rats. The mechanism likely involved a reduction of the protein and mRNA levels of NLRP3, Caspase-1, and IL-1β in the cortex of CIS rats, which may protect the cortical tissue and play a therapeutic role."
Alcoholic Liver Disease + Astragalus membranaceous
The Journal Phytomedicine report "This study is the first to reveal the mechanism of Alcoholic Liver Disease (ALD) protection through Astragaloside IV (AST-IV) a saponin isolated from Astragalus membranaceus (AM) from the perspective of metabolomics and network pharmacology. Therefore, a novel target has been identified to exert protection against ALD. This study provides a reference for ALD treatment."
International Journal of Molecular Sciences report "To our knowledge, this is the first study to investigate the anti-inflammatory properties of extracts obtained from traditional herbs such as artichoke, caigua and fenugreek combined in a unique blend. Here, we show the synergistic effect of this novel formulation, suggesting that the phyto-complex as a whole is responsible for the benefits observed with respect to the single components....Our results indicate that these bioactive molecules are able to interact with and manage the cellular stress pathways, preventing inflammatory and oxidative signaling. Moreover, ACFB seems to play a role in maintaining the intestinal epithelium barrier homeostasis and functions, adding to the several dietary nutrients that exert the same effects"
Integrative Medicine Research Journal report "Acupressure rehabilitation program and qigong exercise (QARP) had long-term sustained efficacy for dyspnea, chest tightness, and cough in patients with COVID-19, especially in young and middle-aged patients, and the effect was significant at the 14th month of follow-up."
Integrative Medicine Research Journal report "The landscape of medical cannabis has evolved dramatically over the past few decades. Once stigmatized and illegal in most parts of the world, cannabis is now recognized for its potential therapeutic benefits, supported by an expanding body of scientific research. However, the transition from prohibition to medical recognition is shaped by complex interactions among scientific advancements, public perception and regulatory frameworks for its legalization.
The Journal Nutrition reports "These results suggested that honey-fried licorice could protect against arrhythmia and alleviate oxidative stress and tissue damage caused by arrhythmia.....Moreover, our results suggested that the therapeutic effect of honey-fried licorice on arrhythmia may be linked to the regulation of the arachidonic acid pathway"
Nutrition Journal report "During a median follow-up of 9.0 years, 445 (3.5%) subjects developed diabetes. Overall, there was an inverse association between the Mediterranean diet adherence (MDA) score and new-onset diabetes .... Moreover, age, sex, BMI, and energy intake significantly modified the association between the MDA score and the risk of new-onset diabetes (all P interactions < 0.05). Greater fruit, fish, and nut intake was significantly associated with a lower risk of new-onset diabetes."
Restorative Medicine report "The substantial historical record for the traditional use of lion’s mane for chronic ailments, together with the results of studies so far, suggest H. erinaceus is safe and has important potential as a neuroprotective and neurotrophic therapeutic agent in neurological conditions.35 Its rich myconutrient composition suggest that using the whole fungus may be most advantageous clinically. More clinical studies are needed to corroborate these conclusions."
The Journal of Health, Population and Nutrition report "According to our result, propolis supplementation can decrease serum levels of IL-6, CRP, and TNF-α; therefore, it might be considered as complementary therapy for the treatment of certain chronic diseases."
Rev Assoc Med Bras report "the patient’s complaints decreased from day 3 and their well-being increased with the use of cranberry only. Specifically, on day 7, the well-being of the cranberry group was higher than that of the fosfomycin group. For this reason, cranberry is a favorable alternative to antibiotics in uncomplicated and simple urinary tract infections."
Phytomedicine Plus Journal report "In conclusion, the data indicates that sesamin can reduce metabolic syndrome and its risk factors. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat metabolic syndrome and its multitude of risk factors."
Blood Pressure + HDL + Quercetin
Nutrition Reviews report "Conclusion: Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design."
Anorexia Nervosa + Psilocybin
The Journal Nature Medicine report ""Results suggest that psilocybin therapy is safe, tolerable and acceptable for female Anorexia Nervosa, which is a promising finding given physiological dangers and problems with treatment engagement."
The Journal BMC Complementary Medicine & Therapies report "The results of this study showed that the use of 700 mg of the hydroalcoholic extract of the aerial parts of M. officinalis daily for 12 weeks by diabetes patients with depression symptoms reduced the depression and anxiety status."
The Journal Evidence Based Complementary and Alternative Medicine report
"The results of our study revealed that inflammatory cytokines IL-6 and TNF-α induce cardiac remodeling in rats after acute myocardial infarction (AMI); Heart-Protecting Musk Pill (HMP) improves cardiac function and ameliorates ventricular remodeling by downregulating the expression of IL-6 and TNF-α and further suppressing the ultrastructural changes of myocardial cells". 
The Journal Hypertension Research report "In conclusion, Binge Drinking (BD) triggers kidney osmotic and ionic imbalances, which contribute to increasing systolic blood pressure. These disturbances could be related in part to Selenium (Se) and selenoprotein GPxs, which decrease oxidative, inflammatory and apoptotic alterations in the kidneys. Se supplementation prevents these changes, improves ionic disturbances, and decreases serum Aldo levels and systolic blood pressure.
 Medicinal Mushrooms
The Journal Evidence Based Complementary and Alternative Medicine report "In summary, our investigations demonstrated that the extract of Inonotus baumii inhibited the proliferation in SMMC-7721 cells and induced cell death, in which apoptosis and autophagy might be involved. These findings provide a further understanding of the mechanism by which I. baumii acts as a potential agent for the prevention and treatment of cancers including HCC. Future research is needed to focus on identifying bioactive compounds that play a role in this medicinal fungus"
The Journal Evidence Based Complementary and Altrnative Medicine report "Together, these results suggest that many Essential OIls (EOs) may be promising for treating people with epilepsy. While some EOs have convulsive properties, these observations cannot be generalized to all EOs. Many EOs have had positive effects on animal models of chronic and acute epilepsy. Because different EOs affect different targets, blends and formulations of EOs should be considered. Future experiments including human clinical trials should also be considered as a next step in verifying whether EOs might be used as antiepileptic drugs (AEDs) in people with epilepsy.
The International Journal of Molecular Science report "In conclusion, we support the notion that curcumin could be considered as a wound healing agent, especially if topically administered. However, most of the current knowledge is derived from in vitro and in vivo investigations, while studies in wound patients remain scarce or controversial. Moreover, since nutrition and nutrients in general might affect the wound healing process, nutritional assessment of patients at risk of non-healing wounds could be the first step towards prevention and treatment. However, further research is recommended to develop appropriate nutritional approaches for wound management."
The Journal Nutrients report "This is the first report to clarify that zinc administration improves liver function and decreases the cumulative incidence of events and the incidence of hepatocellular carcinoma (HCC) in patients with chronic liver diseases (CLDs), over the course of long-term follow-up. We also confirmed that a serum zinc concentration greater than 70 µg/dL must be maintained to obtain good clinical outcomes, and patients should take more than 90 mg/day of zinc to achieve the aforementioned serum zinc concentration. The effectiveness does not depend on the etiology of the CLD; thus, zinc administration is equally useful for patients with an HCV infection, HBV infection, NASH, or alcohol-related liver diseases. It is necessary to highlight the importance of zinc and to start administering zinc preparations in the clinical setting."
The Journal Phytomedicine report "These results are the first observation of uterine sarcoma cell death induced by Gyejibokryunghwan (GBH) and confirmation of the mechanism of cell death, which occurred through the intrinsic apoptotic pathway. Clinically, uterine sarcoma has a poor prognosis with no appropriate treatment. GBH may become a new treatment modality for uterine sarcoma."
 yellow mustard seeds
The Journal of Nutritional Science report " Melatonin-rich and 1,8-cineole-rich extracts have been successfully obtained from yellow mustard (YM) and small cardamom (SC) seeds, respectively, employing green technology of supercritical CO2 (SC-CO2) extraction. Chemical profiling confirmed the presence of melatonin and 1,8-cineole and co-extractants in the respective extracts........In silico and in vivo studies concertedly concluded that the consortium of bioactive components in the extracts cannot be considered as invalid metabolic panaceas and therefore these ‘green’ extracts could be safely subjected to clinical studies as preventive biotherapeutics for hypercholesterolaemia. These extracts could be consumed per se as hypocholesterolaemic supplements or could be ingredients of new spice-based therapeutic foods."
The Journal of Alternative and Complementary Medicine report "Yoga provided comparable improvement in terms of pain intensity and back-related dysfunction in patients with chronic nonspecific low-back pain (CNLBP) compared to conventional therapeutic exercises (CTEs)"
The Journal Evidence Based Complementary and Alternative Medicine report "We have surveyed and presented an overview of evidence that explains why many medicinal plants are used as traditional treatments for cutaneous wounds and clinical skin disorders. Medicinal plants have been the first line of treatment for trauma, infection, disease, and injury from prehistory. Over millennia, humans have learned to identify and transform the botanical resources from the immediate environment, and with the development of trade, as food and medicine. A great many of these “ancient” and traditional medical plants have been validated to confer therapeutic benefits, albeit not always in controlled clinical trials.......We provide these data in the belief that we still have much to learn from traditional practices, some of which undoubtedly could deliver novel reagents and therapies for today’s therapeutic challenges. Notwithstanding, we recognise that modern medicine and drugs remain effectively inaccessible (and unaffordable) to the majority of the world’s population. For this reason alone, traditional medicine continues to be the first line of treatment, indeed, frequently the only line of treatment for many. With greater understanding of traditional practices comes appreciation and benefit to more of the world’s peoples. We would like to see that this knowledge is not discarded by “modern medicine” but leveraged through investigation to benefit all.
The Journal Evidence Based Complementary and Alternative Medicine report "The literature shows that honey has promising skeletal-beneficial effects in preventing osteoporosis. Many types of honey have been shown to prevent bone loss in various animal models via its high antioxidant and anti-inflammatory properties. Nevertheless, the efficacy of honey seems to be dose-dependent, whereby very high or low dosage will not produce desirable results on the skeleton. We cannot conclude a single effective dose due to the heterogenicity of the study design and honey types. It should be acknowledged that the composition of honey varies according to types and commercial brands and not all will have similar effects to the bone. Types, purity, and chemical constituents need to be considered before applying honey for any health purposes. Nevertheless, this review can serve as guidance for choosing the appropriate honey and its doses in osteoporosis prevention."
The Journal of Alzheimer's Disease report "Collectively, these findings suggest benefits of both aerobic exercise training (AET) and stretching and toning (SAT) exercise on neuropsychological function in amnestic mild cognitive impairment (aMCI) patients. Further studies are needed to better understand the impact of exercise training on neuroimaging biomarkers of AD dementia in older adults."
The Journal Phytomedicine report "Numerous studies have focused on solvent extracts from locust trees (Gleditsia spp.), which contain diverse bioactive components including saponins, flavonoids, and alkaloids. However, because of the undefined nature of such phytochemicals, their clinical application as chemotherapeutic agents has often been limited. This study aimed to evaluate the anti-oncogenic activity of triacanthine, an alkaloid obtained from Gleditsia triacanthos L.Triacanthine inhibits the proliferation, migration, and invasion of bladder-carcinoma cells both in vitro and in xenografted tumors. Unlike cisplatin, which caused a significant loss of body weight, triacanthine had no side effects at doses of up to 10 mg/kg in xenografted mice. Moreover, an acutetoxicity test showed no harmful effects in triacanthine-treated mice. We believe that our results provide valuable information about triacanthine, thereby potentially enhancing the development of chemotherapeutic agents (without side effects) for patients with bladder cancer.
The Journal Epilepsy & Behaviour report "High-dose oral Vitamin D3, 5000 IU/day was safe and well tolerated in subjects with epilepsy. Vitamin D levels increased significantly at 6 and 12 weeks but never exceeded potentially toxic levels, defined as >100 ng/ml. To reduce variability, we will now recruit subjects who only have three or more seizures per month.
The Journal Aging reports "Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation"
The Asian Journal of Pharmaceutical Research and Development report "According to the contextualization of articles and dissertations used as basis for this study, it can be suggested that the plant of the species Taraxacum officinale expresses great importance for the advances in phytotherapy medicine, bringing to the fore pharmacological actions of an anti-inflammatory,
and antimicrobial, anticancer and carcinogenic prevention.It is possible to observe that the leaf and root of Taraxacum officinale has an anti-inflammatory, anticancer and antimicrobial action that is more significant than the flower of this species." 
Seminars in Cancer Biology report " Restoring vitamin C to the normal range in cancer patients is a straightforward strategy that may improve the response to epigenetic therapy. This may enhance disease control and, in younger patients, enable subsequent curative treatment such as transplantation and prolonged survival. Vitamin C supplementation may also increase the catalytic activity of other epigenetic regulators such as histone demethylases, for which new drugs are currently being developed. Because aberrant epigenetic regulation is common to all cancers, the basic effects of vitamin C on the methylation of DNA and histones may have implications far beyond hematological cancers"
The Journal Herbal Medicine report "This review identified moderate quality evidence to suggest that standardised aged garlic extracts are likely to be effective as an adjunct therapy to the standard treatment of hypertension in patient populations with SBP > 140 mmHg. The quality of evidence for the role of garlic in the management of dyslipidaemia is currently low.
The Journal of Traditional and Complementary Medicine report "In this article effort has been made to discuss available pharmacological findings that have been frequently reported for S. officinalis. On the basis of the available literature evidence, this plant shows anticancer, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, hypoglycemic, hypolipidemic, and memory-enhancing effects. The effectiveness of S. officinalis as an antinociceptive, hypolipidemic, and memory-enhancing medicinal plant has been confirmed with clinical trials. In addition to the above mentioned effects, a number of other biological actions such as activating benzodiazepine receptors and inhibiting pentylenetetrazole-induced seizure have been shown for S. officinalis in literature"
The Journal Chinese Medicine report "Despite its limitations, this study provides powerful and preliminary data to support the future evaluation of Radix Salviae Miltiorrhizae (RSM) in hepatocellular carcinoma (HCC). RSM may be a potential anti-HCC inhibitor, which can be developed as a therapeutic option for the treatment of cancer."
The Journal Evidence Based Complementary and Alternative Medicine report "Results from these studies are promising and suggest that Cannabidiol (CBD) may have a role in the development of new therapeutic strategies in mental diseases, and they justify an in-depth commitment in this field. However, clinical evidence we show for CBD in psychiatric patients is instead still poor and limited to schizophrenia and anxiety, and it needs to be implemented with further studies carried out on psychiatric patients."
The Journal PLOSOne report "It has been suggested that music can provide a low cost, non-pharmaceutical option for populations suffering from sleep difficulties [49]. The present study aimed to investigate this by gathering data from a general population recruited via self-selection online and through university advertisements without constraint.... Music’s potential for successful use in therapeutic and clinical settings makes it a viable, low cost, side-effect free option in the treatment of sleep loss. The results of this population survey suggest that many individuals are already intuitively using diverse types of music to fight sleep difficulties. Based on the cascade of potential factors that influence music choices that we have identified (body and brain mechanisms linked to anxiolytic properties of music, personal preference, demographic factors) and, in particular, the wide range of reasons we identified that drive music’s potential to improve sleep in different circumstances, future studies can investigate how various flexible and personalized music interventions can be developed to best target the various causes of sleep loss."
The Journal Complementary Therapies in Medicine report "Safety, efficacy, tolerability, and symptom relief were considerable in fig fruit extract in comparison with hydrocortisone 1.0%. This clinical trial suggests that fig fruit extract can be used instead of low potent corticosteroid in mild to moderate cases of Atopic Dermatitis
The Physiological Society report "This study was the first to demonstrate relationships between objective indicators of unhealthy diet and subsequent changes in depressive symptoms in youth. These results add to the growing literature on the role of diet in adolescent depression (Jacka et al., 2011; Khalid et al., 2016; Jacka et al., 2017). The fact that sodium excretion was related to depressive symptoms at follow‐up, but not at baseline, suggests that the effects of sodium on mood may accumulate over time, although replication of these results in other cohorts will be important. Interestingly, potassium excretion was not correlated with depressive symptoms, but emerged as a significant predictor when modeled together with sodium excretion. These results suggest that it is the unique combination of high sodium and low potassium intake that is most predictive of increased adolescent depression."
 Astragalus membranaceus
The Journal Phytomedicine report "With the deep analysis of molecular mechanism of Astragalus membranaceus (AM) and Panax ginseng (PG) in immune regulation, a clear result was obtained that AM and PG had the accurate, broad and comprehensive strategy in regulating human immune system. We speculate that the combination of these two tonic drugs should more effective treatment than the use of single drug in immunosuppression models. That meaningful work could contribute to the interpretation of compatibility of TCM prescriptions. Besides, nervous system was seen to have a close relationship with immune system in this our experiment and many literatures also demonstrated this relationship (Aliev, 1962; Rabin et al., 1988; Sierra Vazquez et al., 1998; Webb and Smith, 1966). So, a deeper insight into enzymatic network around AM and PG will provide us a better evidence of the mechanism of immune regulation, such as reaction site, enzyme activity and its products. In this way, new sight of targets seeking and validation in immune therapy is found and suitable for other systemic disorders.
The Journal of Nutritional Science report "In conclusion, we provided first evidence that coffee consumption reduces HFD-induced liver damage by modulating pathways involved in the gut–liver axis. Coffee reduced the HFD-induced liver steatosis and metabolic derangement by: Reducing hepatic fat deposition possibly through increased fat oxidation in the liver; Increasing cholesterol intestinal efflux; Reducing lipid digestion and ameliorating the intestinal system involved in lipid sensing and energy metabolism regulation, and Ameliorating gut barrier function through a restoration of tight junction proteins in the duodenum and colon.All these mechanisms were accompanied by a negligible change in gut microbiota composition
The Journal of Alternative and Complementary Medicine report "As the current study results indicate the effectiveness of inhalation aromatherapy with Citrus aurantium (neroli oil) (CA) flower essential oil, it may be beneficial as an anxiolytic treatment for acute coronary syndrome (ACS) patients. Considering the high prevalence and importance of anxiety among these patients and necessity of its management, this simple and efficient nursing intervention may be a valuable and important solution. Thus, it may be recommended that aromatherapy with CA essential oil be included in the nursing program of Coronary Care Unit (CCU) patients
The Journal Gastrointestin Liver Disease report "The present study shows that the administration of a 30- day course of a novel oral combination of two nutraceutical compounds, namely curcumin and fennel oil, results in early and consistent symptomatic relief in IBS patients with both subtypes. The benefit is achieved without safety and tolerability concerns. Further studies should target subpopulations of IBS patients while identifying the ideal treatment periods."
The Journal Clinics in Dermatology report "Complementary and alternative medicine approaches are popular among some patient segments due to the perception that they are "natural" and thus are believed to be less likely to be dangerous, to be less toxic, or to cause fewer side effects. In dermatology, these can include aromatherapy, botanicals, and essential oils (plant extracts). Preliminary evidence, biological activity studies, and small pilot clinical trials conducted outside of North America, mostly in young adults, suggest that some may have value in acne treatment. "
The Journal Evidence Based Complementary and Alternative Medicine report "Treatment with gingerols fractions (GF) and vitamin D for two weeks significantly improves delayed diabetic wound healing. The data showed that vitamin D and gingerol activate vascularization, fibrin deposition (HPX, FN, and collagen), and myofibroblasts in such manner to synthesize new tissues and help in the scar formation"
The Journal Planta Medica report "In conclusion, Silymarin-enriched extract (SEE) extract and its bioactive compounds have an antiproliferative effect against human prostate cancer cells (PC-3) cells and also exert an additive effect when combined with Doxorubicin (DXR). Even though the combinational scheme of DXR‑SEE enhances the DXR induced protective autophagy in its initiative steps, it finally suppresses the autophagolysosome degradation, leading to an excessive cell death through the induction of apoptosis; however, more studies are needed to further clarify how these alterations of the autophagic potential serve as a death signal. Since SEE extract highly sensitizes DXRmediated cytotoxicity in PC-3 cells, it gathers the scientific interest regarding its potential application as an adjuvant PCa treatment.
The British Journal of Nutrition report "The review indicates that POM has the potential to enhance endurance and strength performance and to expedite post-exercise recovery by conferring antioxidant and antiinflammatory effects and improving cardiovascular responses during and following exercise. However, positive effects of Pomegranate (POM) supplementation are more likely when POMj contains >0·7 g total polyphenols/0·5 litre, when large muscle mass exercise is engaged and when POMj is ingested at least 60 min before exercise. Therefore, the inclusion (750 ml/d) of polyphenol-rich POM in the diet of active people prior (60 min) and after exercise (during 48 h) could be beneficial for their physical performance and muscle recovery during and following the physical tasks. However, further research is required to assess how chronic POM supplementation impacts the physiological and performance adaptations to exercise training to help optimise POM supplementation guidelines for a range of exercise setting"
The Journal Complementary Therapies in Medicine report "In conclusion, Tai Chi was significantly effective in the management of FM-related syndromes, such as pain, sleep, depression, and fatigue, and consequently reduced the total FIQ score. This review recommends Tai Chi as an alternative to standard care for Fibromyalgia (FM) patients. Further conclusions regarding the effectiveness of Tai Chi compared with conventional therapeutic exercises such as aerobic exercise cannot be firmly drawn due to limited evidence."
The Journal Explore report "Consumption of flixweed or fig, compared to a control group, caused a significant improvement in Irritable Bowel Syndrome (IBS) symptoms including frequency of pain, distention, frequency of defecation and hard stool. Also, the findings showed a significant increase in quality of life, as well as satisfaction with overall bowel habits. However, flixweed and fig intake had no significant effects on abdominal pain severity and C-reactive protein levels."
The Journal Nutrients report "In conclusion, soybean-derived isoflavone glycosides (SIF) showed effectiveness in reducing inflammatory responses in vivo and in vitro. Our study demonstrated the inhibitory effects of SIF on the physiological and histological inflammatory response in DSS-induced colitis in vivo and SIF inhibited the activation of macrophages due to its suppression of NF-kB activation in LPS-stimulated RAW264.7 macrophages in vitro. Our findings suggested that SIF is a potential therapeutic compound and/or functional dietary supplement to prevent inflammatory-related diseases including Inflammatory bowel diseases (IBDs)"
The Journal Phytotherapy Research report "In summary, saffron and its components show significant pharmacological properties and could exert potential therapeutic effects in a wide spectrum of diseases, such as depression, atherosclerosis, diabetes mellitus, neurodegenerative diseases, cancer, and sexual dysfunction. Despite there being promising preclinical results, further investigations are necessary to confirm the effective use of “Red Gold” and its possible applications in clinics"
The Journal Evidence Based Integrative Medicine report "Conclusions. All participants’ microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects."
The Journal Circulation report "In summary, we found that greater intake of sugar-sweetened beverages (SSBs) was associated with a higher risk of mortality and showed a graded association with dose. Intake of artificially sweetened beverages (ASBs) was associated with total and CVD mortality at high intake levels mostly among women and warrants further confirmation. Replacing SSBs with ASBs was associated with a moderately lower risk of mortality. Our results support recommendations and policies to limit intake of SSBs and to consume ASBs in moderation to improve overall health and longevity.
The Journal of Herbal Medicine report "In the light of published data on antidiabetic plants, this review demonstrates that the use of natural medicines can easily become part of the health vernacular. Many medicinal plants are increasingly being utilised to combat diabetes primarily as herbal drugs; others as antioxidants, nutraceuticals, food additives and supplements. Indeed, current research efforts underscore that the use of medicinal plants to control diabetes is no longer in a medical and pharmacological grey area. The use of medicinal plants to manage diabetes is a prelude to a more realistic and more inclusive global health order. Undoubtedly, medicinal plants will increasingly become part of the antidiabetic drug mix. If there is a long-term remedy for diabetes, it must lie in nature's pharmacy of putative antidiabetic agents from plants. While evidence-based phytotherapy for diabetes is finding its voice in the world again, the use of medicinal plants to manage diabetes is a daunting reality as much as it is a bountiful prospect. There is an urgent need to put the use of herbal remedies and other natural products into the correct medical perspective"
The Int Journal of Molecular Science report "Topical applications of plant oils may have different effect on the skin according to their composition and the pathophysiological context of the skin. The composition varies by different extraction methods. When applied topically, constituents of plant oils (triglycerides, phospholipids, FFAs, phenolic compounds and antioxidants) may act synergistically by several mechanisms: (i) promoting skin barrier homeostasis; (ii) antioxidative activities; (iii) anti-inflammatory properties; (iv) direct and indirect (upregulation of antimicrobial peptides) anti-microbial properties; (v) promoting wound healing; and (vi) anti-carcinogenic properties. Future studies can add to current findings to allow for better understanding of these oils, with the potential to develop dermatological treatments and skin care products using these oils."
The Journal Alternative and Complementary Medicine report "Retrospective database analysis demonstrates the potential that acupressure can be an effective, complementary nonpharmacologic tool for relief pain and anxiety with a high degree of participant satisfaction"
The Journal Atherosclerosis report "In conclusion, our findings from this large Japanese cohort supported a significant inverse association between chocolate consumption and risk of developing stroke in women but not in men. However, residual confounding could not be excluded as an alternative explanation for our findings. Sex-specific analysis may be needed in further studies examining the health effect of chocolate consumption"
The Journal Nutrition Research report "In conclusion, chronic proprietary spearmint extract (PSE) supplementation improved scores in 2 domains of attention: complex and sustained. Benefits were also observed during 2 specific tests: the shifting attention test and the 4-part continuous performance test. The present study is the first time that improved attention has been demonstrated after chronic consumption of PSE in young, healthy individuals and provides further support to the body of evidence indicating that PSE is an efficacious nootropic.
The European Journal of Integrative Medicine report "Osteoarthritis (OA) is one of the most common and fast-growing chronic diseases among older adults. The aim of this study was to assess the effect of acupressure therapy on pain, stiffness, and physical functioning of a knee affected by osteoarthritis......Conclusion Acupressure may be an effective intervention for reducing the pain, stiffness, and improving the function of knees with osteoarthritis."
The Journal Evidence Based Complementary and Alternative Medicine report "In conclusion, in this mouse model of bone cancer pain yokukansan (YKS) significantly lessened cancer pain behavior by suppressing MMP-9 expression, suppressing the expression in bone tissue in the early phase and in the spinal cord in the late phase of pain development.
Yokukansan (YKS) is a Japanese herbal medicine consisting of 7 main galenicals, Atractylodes lancea, Poria sclerotium, Cnidium officinale, Angelica acutiloba, Bupleurum falcatum, Glycyrrhiza uralensis, and Uncaria rhynchophylla 
The Journal of Ethnopharmacology report "Conclusion The results of this study provide new scientific evidence for the traditional use of local medicinal plant species C. lansium, L. indica, P. bleo, S. crispus, V. amygdalina and V. trifolia in cancer treatment. These results highlight the importance of the upkeep of these indigenous plants in modern society and their relevance as resources for drug discovery."
The American Journal of Psychiatry report "The results of this double-blind randomized placebo controlled trial indicated that administration of 400 mg or 800 mg of CBD reduced cue-induced craving and anxiety in heroin-abstinent individuals, suggesting a potential role for CBD to alleviate clinical signs and symptoms critical to the continued cycle of addiction. The effects of CBD on drug cue–induced craving and anxiety were evident soon after acute exposure to the drug (session 1). In addition, there was a protracted effect on these measures 1 week after short-term repeated administration of CBD (session 4). CBD also tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels that were induced by salient drug cues. Importantly, CBD administration (at 400 mg or 800 mg) was associated with only mild adverse events"
The Journal Evidence Based Complementary and Alternative Medicine report "Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant therapy in clinical use and has been shown to be effective in cancer patients. However, the mechanism of JDTYS is still unclear. Therefore, the aim of the present study is to investigate the chemopreventive effects of JDTYS for esophageal squamous cell carcinoma (ESCC) and to clarify the potential mechanism.....In summary, we provided evidence that JDTYS significantly inhibits the formation of esophageal precancerous lesions induced by NMBA. The inhibitory effect of JDTYS on esophageal precancerous lesions is related to downregulation of proliferation related proteins Ki67 and c-Jun and modulation inflammation related proteins COX-2, NF-κB, PTX3, and CD11B.
The Journal Phytotherapy Research report "In conclusion, the present study shows that the anxiolytic‐like effect of Citrus sinensis essential oil seems to be mediated by the nitrergic system."
The Journal of the National Cancer Institute report "In summary, we found higher vitamin E status, as measured by serum alpha-tocopherol concentrations from two blood collections taken three years apart, were related in a dosedependent manner to decreased lung cancer incidence during a 28-year period. The inverse association was observed primarily among younger men and those with fewer cumulative years of cigarette smoking. Our findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.
The Journal Evidence Based Complementary and Alternative Medicine report "The results of current experiments indicated that wound healing effects of Callicarpa nudiflora water extract (CNE) were quicker and better than Vaseline and Silver sulfadiazine (SSD) in a deep second-degree scald rat model. Macroscopic difference of wound closure in proliferation and tissue remodeling phase suggested a positive effect of CNE on wound closure after 12 days since scald wound induction. The 20% CNE-treated group exhibited structures of epidermis and dermis were well restored with minimum of scars on the last phase of healing."
The Journal Molecular Psychiatry report "Excess oxidative stress is increasingly appreciated to participate in the pathophysiology of brain disorders, and decreases in the major antioxidant, glutathione (GSH), have been reported in multiple studies.....We found that the naturally occurring isothiocyanate sulforaphane increased blood GSH levels in healthy human subjects following 7 days of daily oral administration. In parallel, we explored the potential influence of sulforaphane on brain GSH levels in the anterior cingulate cortex, hippocampus, and thalamus via 7-T magnetic resonance spectroscopy. A significant positive correlation between blood and thalamic GSH post- and pre-sulforaphane treatment ratios was observed, in addition to a consistent increase in brain GSH levels in response to treatment. This clinical pilot study suggests the value of exploring relationships between peripheral GSH and clinical/neuropsychological measures, as well as the influences sulforaphane has on functional measures that are altered in neuropsychiatric disorders.
* Sulforaphane is a natural phytochemical compound abundant in the seeds and sprouts of cruciferous plants such as broccoli. 
The Journal Planta Medica report "In this study, wounds treated with Rosehip Oil (RO) healed rapidly and the period of epithelialization time was shortened when compared to that of the control group. Wounds in the RO group showed lower infiltration of inflammatory cells, enhanced proliferation of fibroblasts, collagenation, angiogenesis, and better collagen remodeling (basket weave meshwork of collagen). These provided strong support for the effective healing activity and scar-improving efficacy of RO
The Journal Evidence Based Complementary and Alternative Medicine report "This study demonstrates that a compound of four Chinese herbs, namely, P. lobata (Willd.), S. miltiorrhiza, S. chinensis, and S. marianum, can be a novel therapeutic agent on preventing and reversing Alcoholic Liver Fibrosis (ALF), and the underlying mechanism of the protective effects may involve TGF-β1/Smad signaling pathway.
The Journal Alternative and Complementary Medicine report "Through the analysis of green tea consumption and Coronary Arterial Disease (CAD) related biomarkers, we concluded that a small amount, high-frequency green tea consumption was associated with a reduced risk of CAD in female populations in Guangzhou, China, and the association might be partly due to altered CAD-related biomarkers.
The Journal of Functional Foods report "These findings are consistent with clinical data indicating that elderberry can mitigate the duration and severity of influenza symptoms in patients. The action of elderberry is both direct – suppressing viral entry, affecting the post-infection phase, and viral transmission from cell to cell, and indirect – by modulating the release of cytokines such as IL-6, IL-8, and TNF. These data support the use of Sambucus nigra berries as nutraceutical ingredients for the management of influenza infection.
The European Journal of Integrative Medicine report "The application of rose oil aromatherapy by inhalation reduced the scores of preoperative anxiety of patients undergoing septorhinoplasty/rhinoplasty."
The Journal Alternative and Complementary Medicine report "The results indicated that a combination of Melissa officinalis plus Nepeta menthoides was effective for the treatment of insomnia. The severity of insomnia, total PSQI, sleep latency, daytime dysfunction, and sleep disturbance indicators all decreased in the treatment group, and the sleep efficacy, sleep quality, and sleep duration were increased.
The Journal Military Medical Research report "Our findings have honed the existing knowledge base on therapeutic horseback riding (THR), a beneficial intervention for veterans with PTSD, by identifying a clinically meaningful dosage of THR. A 3-week THR program was effective, and a 6-week program produced clinically significant outcomes in PTSD levels. Older veterans, such as the majority in our sample, may have been diagnosed with PTSD decades ago; THR may be particularly promising for them. It may be important for health systems to recognize such promise by supporting THR as a reimbursable complementary therapy."
The British Journal of Nutrition report "This dietary intervention study in healthy volunteers identified specific effects of dark chocolate on digestive and cerebral function. These findings add to the body of literature indicating that naturally occurring substances in chocolate, in particular cocoa flavanols, in isolation and in combination, have measurable biological effects. Future research will establish if these are clinically relevant. Acute and chronic disturbances in bowel function are common in the community and can be a major burden....If the “nutraceutical” effects of dark chocolate or cocoa-based products are confirmed, then this could be a safe and popular alternative to pharmacological treatment. If, as expected, there are also positive effects on well-being, then the combination of peripheral and central effects could be a much needed, novel approach for the treatment of participants with conditions such as irritable bowel syndrome that are affected by both disorders of digestive function and mood
The Journal of Psychoactive Drugs report "Results indicated that psilocybin enhanced divergent thinking and emotional empathy the morning after use. Enhancements in convergent thinking, valence-specific emotional empathy, and well-being persisted seven days after use. Sub-acute changes in empathy correlated with changes in well-being. The study demonstrates that a single administration of psilocybin in a social setting may be associated with sub-acute enhancement of creative thinking, empathy, and subjective well-being. Future research should test whether these effects contribute to the therapeutic effects in clinical populations."
The Journal Nutrition Research report "RNA-Seq Expression Profiling analyses from a pilot clinical trial in which women with breast cancer consumed 2 ounces of walnuts per day for 2 to 3 weeks between the diagnostic biopsy and subsequent surgery showed that gene expression in the tumor was modified in ways expected to slow proliferation, reduce inflammation, reduce metastasis and to increase cancer cell death. It seems likely that if gene expression was modified in the tumor due to consumption of walnuts, then gene expression of any metastatic cells should also be modified thus decreasing risk for cancer recurrence."
The Journal Clinical Nutrition report "There is a large body of evidence which supports the role of inflammation in the pathophysiology of mental health disorders, including depression. Dietary patterns have been shown to modulate the inflammatory state, thus highlighting their potential as a therapeutic tool in disorders with an inflammatory basis....These results provide an association between pro-inflammatory diet and risk of depression. Thus, adopting an anti-inflammatory diet may be an effective intervention or preventative means of reducing depression risk and symptoms
The Journal of Child and Adolescent Psychopharmacology report "This study provides evidence for satisfactory outcomes with saffron in treatment of ADHD. In this double-blind randomized trial of C. sativus versus methylphenidate in treatment of ADHD, C. sativus was as effective as methylphenidate. The clinical relevance of these findings was emphasized by improvements seen in both Parent and Teacher Rating Scale scores. Also C. sativus was safe and showed equally or lesser adverse effects.
The Journal Alternative and Complementary Medicine report "This study aimed at identifying areas of consensus among naturopathic experts in IBS. Panelists reached consensus on a 45-item list of reasonable naturopathic approaches for IBS in North America. Consensus was reached in the domains of general approaches to IBS, office visits, tracking progress, testing, interventions, and resources. It is our intention that these results will inform protocol development in future randomized controlled trials. We believe that there is opportunity for future refinement of these consensus guidelines, reflecting an evolving field of evidence-informed practice of naturopathic medicine."
 Curcuma zedoaria
The Journal Complementary and Alternative Medicine report "E-Zhu (Curcuma zedoaria) is known as a classical traditional Chinese medicine and widely used in the treatment of cancers, cardiovascular disease, inflammation, and other diseases. Its main components include curcumol and curcumin, which have anti-inflammatory and antifibrosis effects.
In conclusion, our findings perfectly supported the hypothesis demonstrated that curcumol and curcumin could reduce the expressions of inflammatory factors by inhibiting the NF-κB signaling pathway and TGF-β1/Smads signaling pathway. 
The Journal Complementary and Alternative Medicine report " this review included a summary of the data published by many researchers related to the protective and/or treatment role that propolis and/or its active ingredients play against gastrointestinal associated disorders that affect humans. The focus was on the following: oral mucositis, ulcerative colitis, gastrointestinal cancers, and gastric ulcers. Analysis of the published work indicated that the efficacy of propolis in the treatment of gastrointestinal disorders could be attributed to its antioxidants and anti-inflammatory properties.
The Journal Alternative and Complementary and Alternative Medicine report "Despite widespread use, there remains a paucity of research exploring cancer patients’ experiences of receiving complementary therapy treatment. We wanted to gain insight into the experiences of patients using a complementary therapy outpatient service offering aromatherapy, massage, reflexology and Reiki....Qualitative comments collected from this evaluation indicate that complementary therapies can address both physical and emotional concerns often simultaneously and provide a unique therapeutic space for patients. Many patients have not had this experience before and this may introduce them to new methods of addressing complex multi dimensional issues resulting from living with a cancer diagnosis."
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