The Journal Alternative and Complementary Medicine report "This study showed that acupressure produced the largest effect when performed twice daily for 2 weeks. The effect of acupressure on agitation had an immediate onset in week 1, resurged in week 4, and was sustained until week 6. The effect of acupressure on cortisol was mild in week 1 and peaked only in week 4. Delivering acupressure to agitated PWD was feasible, with a fairly good adherence rate."
The Journal Alternative and Complementary Medicine report "This study identified several citations in the classical literature that described conditions characterized by profound memory impairment, but whether these were due to AD pathology or other causes remains uncertain. What is evident is that memory impairment associated with aging was a recognized condition. The formulas recommended for this condition varied considerably in name, but certain ingredients, including P. cocos, P. tenuifolia, R. glutinosa, P. ginseng, and Acorus species, appeared in multiple formulas and in multiple books for memory impairment in the context of aging. This same group of TMs also appeared in a systematic search of the largest printed compendium of Chinese formulas.41 These five TMs remain in clinical use for memory impairment,37,38 and experimental studies suggest biological activities relevant to AD."
The Journal of Alternative and Complementary Medicine report "Two studies used Melissa oil and 5 others used lavender oil. The studies described different methods of administration for the oils, including spraying and rubbing over various body organs. The duration of treatment differed among the studies. In 3 studies the investigators concluded that the treatment was not effective and in 3 that it was effective; in 1 study no clear conclusion could be drawn.
Conclusions: The difference between positive and negative studies was not explained by differences in the study population, the type of oil, or the duration of treatment. The significant difference apparently stems from the method of administration. When the oil was applied close to the olfactory system the outcome was positive. A study should be designed to assess the effect of the site of application of aromatherapy.
The Journal Evidence Based Complementary and Alternative Medicine report "The subchronic administration of Melissa officinalis (MO) led to an improvement of long-term memory of rats; however the mechanisms of MO action are probably more complicated, since its role as a modulator of beta-secretase activity (due to inhibition of BACE1 mRNA expression in frontal cortex) should be taken into consideration. It should be noted that we have studied a crude extract from leaf of Melissa officinalis, not a single pure chemical compound. This plant extract is a complex mixture, and its action may be a result of the summation of activities of several components (synergism/additive action of caffeic acid with salvianolic acids, rosmarinic acid, and others). In the case of extract from leaves of Melissa officinalis, it is possible that interactions occur between the 40 chemical compounds identified by HPLC system. Taken together, it seems that the MO activity represents a possible option as complementary interventions to relieve the symptoms of mild dementia.
The FASEB Journal report "Cognitive performance for dual or single tasking were worse in thevitamin D insufficient group. Since counting backward is a mental tracking task, which is a component of executive function, our results support a relationship between vitamin D insufficiency and executive dysfunction."
The Journal Evidence Based Complementary and Alternative Medicine report "Taken together, our study showed that Extract of Ginkgo biloba (EGb) can ameliorate the impairment of learning and memory abilities of rats induced by repeated high sustained +Gz exposure; the underlying mechanisms appeared to be related to the signal regulation on the cholinergic system and antioxidant enzymes system."
BMC Complementary and Alternative Medicine report "We have developed a method to increase the level of Rg3 in ginseng roots without the need for a thermal process. The neuropharmacological effects of Rg3GE were tested. Rg3GE exhibited potent memory-stabilizing effects, as assessed by the Morris water maze test, and inhibited scopolamine-induced acetylcholinesterase activity in the hippocampus. Rg3GE also decreased the activation of NF-κB. The effects of Rg3GE were better than or similar to those of RGE. Our findings suggest that Rg3GE may improve cognitive deficits via the inhibition of acetylcholinesterase activity and inflammation."
The American Botanical Council report "This systematic review is unique and valuable because the authors conducted large-scale pooled analyses of individual patient data. This is opposed to the typical meta-analysis where authors evaluate mean data extracted from a published report. The pooled analyses support the conclusion that 240 mg/day EGb 761 is safe and moderately effective for the treatment of outpatients with dementia and mild to moderate Behavioral and psychological symptoms of dementia (BPSD)"
BMC Complementary and Alternative Medicine report "Our findings suggest that Salvia Miltiorrhiza may be a promising therapeutic candidate in vascular dementia because of its protective effects against damage to the white matter and hippocampus after BCCAo.
The Intl Journal of Alzheimer's Disease report "These findings support further consideration of music as a modifiable protective factor against dementia and cognitive impairment.
This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population. Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration. This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of therapeutic trials with vitamin D. It is, therefore, urgently warranted to further establish the role of this potentially neuroprotective vitamin in preventing and halting progressive neurodegeneration in AD patients.
European Journal of Applied Physiology report "These findings suggest that dietary NO3 − enhances repeated sprint performance and may attenuate the decline in cognitive function (and specifically reaction time) that may occur during prolonged intermittent exercise."
The Nutrition Journal report "Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21 % compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects.
The American Journal of Clinical Nutrition report "There is growing evidence that the synergy and interaction of all of the nutrients and other bioactive components in nuts and berries can have a beneficial effect on the brain and cognition. Regular nut consumption, berry consumption, or both could possibly be used as an adjunctive therapeutic strategy in the treatment and prevention of several neurodegenerative diseases and age-related brain dysfunction. A number of animal and a growing number of human studies show that moderate-duration dietary supplementation with nuts, berry fruit, or both is capable of altering cognitive performance in humans, perhaps forestalling or reversing the effects of neurodegeneration in aging."
The American Botanical Council - Herbal Gram report "Overall, the results of this meta-analysis suggest that 240 mg daily intake of EGb 761 is effective in improving cognition, ADL, and clinical global impression in those suffering from AD and/or VaD, with minimal adverse side effects. This phytomedicinal formulation may be a useful adjuvant therapy in those suffering from cognitive decline."
The Journal eCAM report "In conclusion, the combination of Coriolus versicolor polysaccharide (CVP) and Ginkgo Flavonoid (GF) shows a synergistic effect with respect to improving the memory of D-gals and AlCl3-induced AD mouse model. The elevated inflammation and oxidation levels in the brain tissue of AD mice were found to be alleviated by the combination treatment. Our research provides a new insight into the treatment of dementia."
BMC Complementary and Alternative Medicine report "Finally, asiaticoside prevents amyloidogenesis that precedes neurodegeneration in patients with Alzheimer’s disease"
The American Journal of Clinical Nutrition report "The beneficial effect of B vitamin treatment on brain atrophy was observed only in subjects with high plasma ω-3 fatty acids. It is also suggested that the beneficial effect of ω-3 fatty acids on brain atrophy may be confined to subjects with good B vitamin status."
The Journal Nutrition report " These results suggested that total B vitamins intake is associated with cognitive function in cognitively impaired Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) elderly, and the association is stronger in AD patients."
Planta Medica report "To date, evidence from recent studies suggests that commonly used medicinal herbs and their phytochemicals could potentially be used to treat AD. Although these studies focus on the efficacy of inhibiting AD development, and research on humans is limited, numerous findings demonstrate the possibilities of the use of medicinal herbs for the treatment of AD. The approach to investigate the potential treatment of AD may support drug development from herbal medicine."
Evidence Based Complementary and Alternative Medicine Journal report
"Clinical research has evaluated the efficacy of saffron, but not of crocin, in a narrow range of memory disorders (AD). The results indicated that its effects on cognition, although modest, were not different than those expressed by donepezil and memantine. In this context, it is important to emphasize the good safety profile of saffron which was revealed in all clinical experimentations. There is no information, however, on the potential efficacy of saffron and crocin in memory disorders which occurred in other pathologies such as brain ischemia, traumatic brain injury, and cognitive deficits related to schizophrenia. The potential role of saffron and crocin as adjunctive agents, in combination with an AChE inhibitor or memantine, for the treatment of memory disorders has not been investigated so far."
PLOS One report "Huperzine A appears to have beneficial effects on improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease. However, the findings should be interpreted with caution due to the poor methodological quality of the included trials."
Medical Xpress report "A world authority on the link between human exposure to aluminium in everyday life and its likely contribution to Alzheimer's disease, Professor Christopher Exley of Keele University, UK, says in a new report that it may be inevitable that aluminium plays some role in the disease."
Newswise report "Women who are anxious, jealous, or moody and distressed in middle age may be at a higher risk of developing Alzheimer’s disease later in life, according to a nearly 40-year-long study"
The Journal Nutrients reports "This result suggests that green tea consumption may be effective in improving cognitive function or reducing the progression of cognitive dysfunction; however, long-term large-scale controlled studies are needed to further clarify the effect. "
NewsMedical report "Studies have shown that people with symptoms of depression are more likely to develop dementia, but we haven't known how the relationship works," said study author Robert S. Wilson, PhD, neuropsychiatrist at the Rush Alzheimer's Disease Center and lead study investigator.
New research bolsters the belief that long-term use of a prescription drug commonly used to alleviate anxiety, panic attacks and sleep problems is linked in aging patients to a higher risk of Alzheimer’s disease. Researchers in France and Canada, using data from Quebec’s health insurance program, found that Alzheimer’s risk was up to 51 percent higher in elderly people who used benzodiazepines for three months or more. The researchers said the link appeared even stronger with longer duration of use or longer-acting benzodiazepines.
The American Botanical Council, Herbclip report "Finding ways to enhance brain activity, such as word puzzles, studying new subjects, exercising to increase oxygen capacity, and some form of meditation to relax the mind, can maintain and even enhance cognitive function. Bacopa, green tea, and pomegranate, among other herbs, can also support the brain's various processes"
The Journal Menopause report "Soy Isoflavone (SIF) supplementation seems to have a positive effect on improving summary cognitive function and visual memory in postmenopausal women
The Journal Neurochem. Res. report "Our findings lend support to a novel therapeutic strategy, associated with these vitamins (E and C), to the cognitive dysfunction observed in depression and other stress related diseases."
The Journal Evidence Based CAM report "The standardized Ginkgo biloba extract EGb 761 has well-described antioxidative activities and effects on different cytoprotective signaling pathways. Consequently, a potential use of EGb 761 in neurodegenerative diseases has been proposed. A common characteristic feature of a variety of such disorders is the pathologic formation of protein aggregates, suggesting a crucial role for protein homeostasis. These results demonstrate a novel activity of EGb 761 on protein aggregates by enhancing proteasomal protein degradation, suggesting a therapeutic use in neurodegenerative disorders with a disturbed protein homeostasis.
....It was shown that in Alzheimer's Disease the treatment with EGb 761 provides protective effects through a combination of antioxidative , free radical scavenging , antiamyloidogenic , and antiapoptotic properties ."
The American Botanical Council report "The authors conclude that the general lack of evidence prevents them from drawing conclusions for most neuropsychiatric conditions. However, the meta-analysis of dementia studies shows that ginkgo provides benefits for cognition and ADL. The authors state that the benefits for dementia and schizophrenia were modest and that some studies showed statistical improvements that were not necessarily clinically meaningful. Nonetheless, the authors conclude that despite heterogeneous results, the evidence supports the use of the proprietary standardized ginkgo extract in patients with dementia and as an adjunct therapy for patients with schizophrenia."
The Journal Biomed Research International report " In general, the very few studies that have been done suggested that higher intake of fruits, vegetables, fish, nuts, legumes, cereal, lower intake of meats, high fat diary, sodium, sweets, and refined grains seemed to be associated with reduced risk of Alzheimer's Disease.
The Journal Molecular Pharmaceutics report "Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease."
Psychopharmacology reports "Our findings provide first evidence for the putative beneficial effect of green tea on cognitive functioning, in particular, on working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections. Modeling effective connectivity among frontal and parietal brain regions during working memory processing might help to assess the efficacy of green tea for the treatment of cognitive impairments in psychiatric disorders such as dementia"
The Journal Behavioural Brain Research report "Chronic administration of curcumin significantly improved memory retention in both tasks, attenuated oxidative damage, acetylcholinesterase activity and aluminium concentration in aluminium treated rats (P<0.05). Curcumin has neuroprotective effects against aluminium-induced cognitive dysfunction and oxidative damage."
Evidence Based Complementary and Alternative Medicine Journal report "Kamikihito (KKT) reverses axonal degeneration, in part through its action as an exogenous PP2A stimulator. In Japan, Korea, and China, KKT is already prescribed as a traditional formula for clinical medication. The usefulness of KKT as an anti-AD drug with the crucial property of reversing memory dysfunction must be confirmed by clinical studies."
Science Daily Report "A chemical that's found in fruits and vegetables from strawberries to cucumbers appears to stop memory loss that accompanies Alzheimer's disease in mice, scientists have discovered. In experiments on mice that normally develop Alzheimer's symptoms less than a year after birth, a daily dose of the compound -- a flavonol called fisetin -- prevented the progressive memory and learning impairments. The drug, however, did not alter the formation of amyloid plaques in the brain, accumulations of proteins which are commonly blamed for Alzheimer's Disease. The new finding suggests a way to treat Alzheimer's symptoms independently of targeting amyloid plaques."
The American Botanical Council report "The authors conclude that neurovascular coupling is related to cognitive performance and cerebral white matter structural integrity in elderly subjects with vascular risk factors. In addition, they conclude that neurovascular coupling can be modified by cocoa. Cocoa had an effect irrespective of the amount of flavanols, indicating that there is something else in cocoa that is producing the benefit or that coupling is so sensitive to flavanols that even the small amount in the flavanol-poor group was enough to produce a benefit"
The Journal Acupuncture and Meridian Studies reports "Of the 110 different natural products identified, those most frequently cited for forgetfulness were yuan zhi (Polygala tenuifolia), fu shen (Poria cocos), and chang pu (Acorus spp.), all of which have been cited repeatedly over the past 1800 years and appear among the 31 herbs indexed in a modern pharmacopoeia. By providing a complete, hierarchically organized list of herbs for a specific disorder, this approach can assist researchers in selecting herbs for research."
The Journal Neurology report on a study back in 1999 "These results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life.
A study in an animal model at Saint Louis University found "Enhanced extracts made from special antioxidants in spearmint and rosemary improve learning and memory, We found that these proprietary compounds reduce deficits caused by mild cognitive impairment, which can be a precursor to Alzheimer's disease," said Susan Farr, Ph.D., research professor geriatrics at Saint Louis University School of Medicine"
Dr. Mercola reports on two exciting Alzheimer's Advances - a test using Peanut Butter and a study on Coconut oil and also tips for maintaining healthy brain function
Amyloid b-toxicity + Seonghyangjeongkisan
The Journal of Evidence Based Complementary and Alternative Medicine report on a combination of 16 Korean Medicinal Herbs and their effects on Alzheimers Disease the "results demonstrate that Seonghyangjeongkisan reduces amyloid b-induced toxicity in the brain, suggesting that it may be a useful complementary therapy against Alzheimer’s disease."
The American Botanical Council report on the effects of Bacopa / Brahmi on Attention, Working Memory, Cognitive Processing, and Cholinergic Function in Healthy, Elderly Subjects "The authors conclude that bacopa enhanced attention, cognitive processing, working memory, and cholinergic function. Bacopa may suppress the function of AChE in the brain, leading to increased levels of acetylcholine which can enhance attention and memory. Since mild cognitive impairment and early Alzheimer's disease are due in part to a decline in acetylcholine, bacopa may benefit these patients,
The Journal of Medicinal Foods report on a study on tart cherries and essential Fatty Acids and cognitive deficits and conclude: "These findings indicate that TBR (containing tart cherry extract, Nordic fish oil, and refined emu oil) has the potential to serve as an adjunctive treatment which may help reduce the severity of cognitive deficits in disorders involving cholinergic deficits, such as Alzheimer's Disease."
Genetics and high blood pressure appear to interact to increase deposits in the brain of a protein involved in the pathology of Alzheimer's disease, researchers reported.
In a cross-sectional study of cognitively normal older adults, brain levels of beta-amyloid were highest in volunteers with both hypertension and the ε4 variant of the apolipoprotein E gene, according to Karen Rodrigue, PhD, of the University of Texas at Dallas, and colleagues.
But people with just one of those factors were not significantly different in terms of beta-amyloid deposition in the brain from volunteers with neither, Rodrigue and colleagues reported online in JAMA Neurology.
Researchers at the University of Michigan have found that a molecule in green tea can prevent misfolding of specific proteins in the brain, which is associated with amyloid plaques in Alzheimer's disease.
Chemicals from green tea and red wine may disrupt a key step in the progression of Alzheimer’s disease, a new study shows.
Individuals with the highest levels of cardiorespiratory fitness during middle age were significantly less likely to develop dementia in their senior years, a long-term prospective study suggested.
Among nearly 20,000 participants in the Cooper Center Longitudinal Study, those in the highest quintile of cardiorespiratory fitness at roughly age 50 were 36% less likely than those in the lowest quintile (adjusted hazard ratio 0.64, 95% CI 0.54 to 0.77) to be diagnosed with dementia after age 65
Older adults can improve their decision making and working memory simply by putting on a happy face, a new study suggests.Researchers found that easy mood-boosters -- like giving people a small bag of candy -- helped seniors do significantly better on tests of decision-making and working memory.
The results of a study in the Nutrition Journal conclude "Intake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline."
Researchers have discovered how the chemical properties of China's favorite drink affect the generation of brain cells, providing benefits for memory and spatial learning.
"We have shown that the organic chemical EGCG acts directly to increase the production of neural progenitor cells, both in glass tests and in mice," concluded Bai. "This helps us to understand the potential for EGCG, and green tea which contains it, to help combat degenerative diseases and memory loss."
The dietary supplement citicoline, which is sold over the counter in 70 different countries, including the United States, appears to help memory in patients with vascular mild cognitive impairment (VaMCI) and may hinder cognitive deterioration, new research suggests. Preliminary results from a longitudinal study presented here at the Alzheimer's Association International Conference (AAIC) 2012 showed that at 9 months, there was a significant difference in Mini–Mental State Examination (MMSE) scores in citicoline users vs nonusers.
American Botanical Council - Herbal Gram report on the Efficacy and Tolerability of Ginkgo Extract in Treatment of Alzheimer’s Disease and Vascular Dementia
Medscape report that Increased consumption of blueberries and strawberries appears to slow cognitive decline in older women, according to an analysis of data from the Nurses' Health Study (NHS).
Newswise report on a study that suggests that eating foods that contain omega-3 fatty acids, such as fish, chicken, salad dressing and nuts, may be associated with lower blood levels of a protein related to Alzheimer’s disease and memory problems. The research is published in the online issue of Neurology®, the medical journal of the American Academy of Neurology.
Newswise report on a study from the online issue of Neurology that Daily physical exercise may reduce the risk of Alzheimer’s disease, even in people over the age of 80. “The study showed that not only exercise but also activities such as cooking, washing the dishes and cleaning are associated with a reduced risk of Alzheimer’s disease,” said study author Aron S. Buchman, MD, with Rush University Medical Center in Chicago and a member of the American Academy of Neurology. “These results provide support for efforts to encourage physical activity in even very old people who might not be able to participate in formal exercise but can still benefit from a more active lifestyle.”
Lower blood levels of omega-3 fatty acids are associated with smaller brain volumes and worse cognitive performance, researchers reported.
Medpage Today report that walking speed and hand-grip strength during middle age correlated with cognitive function and stroke risk in older adults,
_An article in Medical News Today report that people who throughout their lives keep their brains active have lover levels of β-amyloid protein, which is the major part of the amyloid plaque in Alzheimer disease.
_Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia
_A Russian Journal reports that Acetyl-L-carnitine in doses of 2250 to 3000 mg per day was well tolerated and recommended for early stage Alzheimer's disease and vascular dementia
_The Journal of Neuroscience report - The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
_Consuming an antioxidant-rich drink for eight months showed a smaller increase in homocysteine levels, compared with a placebo group The effects were even more significant in people with moderate Alzheimer’s disease
_20/10/2010 The Alliance For Natural Medicine have a great article on Alzheimer's disease. 2050 it is predicted that there will be 15,000,000 people with Alzheimer's Disease in the U.S. Researchers gave mice the equivalent of a human dose of 2000 to 3000 milligrams of niacinamide, and the results were shocking. “Cognitively, they were cured,” said Dr. Kim Green, the head of the study. “The vitamin completely prevented cognitive decline associated with the disease, bringing them back to the level they’d be at if they didn’t have the pathology.” Niacinamide also improved memory in mice without Alzheimer’s
_21/10/2010 Following on from yesterday, another article from The Alliance for Natural Medicine on Alzheimer's and coconut oil. At the bottom of the article there is a link to a report by Dr. Mary Newport who used coconut oil to treat her husbands decline into Alzheimer's, she had amazing results