My name is Laura Murphy, I am a Biologist and a practitioner of Natural Medicine, I am a qualified Naturopath, Homeopath, Herbalist and Nutritionist. I am passionate about natural medicine and spend innumerable hours researching evidence based natural therapies and disease and rather than hoard all this valuable information on my computer, I decided to set up this humble website. If you have any questions or suggestions please "contact me"
Look to your health; and if you have it, praise God, and value it next to a good conscience; for health is the second blessing that we mortals are capable of; a blessing that money cannot buy - Izaak Walton
Look to your health; and if you have it, praise God, and value it next to a good conscience; for health is the second blessing that we mortals are capable of; a blessing that money cannot buy - Izaak Walton
PETITION - Free Julian Assange, before it's too late. Sign to STOP the USA Extradition
- Vitamin D metabolite helps stop drug-resistant cancer - NewsWise
- Smoking may impair body's blood pressure autocorrect system - NewsWise
- NY Ends Religious Exemptions for Vaccines, Violating Constitutional Rights of Millions - GreenMed Info
- Assange to Face 5-Day Extradition Hearing in February 2020. Decision on Assange’s fate will not come for at least another eight months - Consortium News
- What You Need to Know About Sea Turtles and Why We Need to Protect Them - EarthDag
- Trump administration eases rules for genetically modified foods, animals - semissourian.com
- DDT still affecting lake ecosystems 50 years after it was banned - UPI.com
- Many breakfast cereals still contaminated by weed killer, report says - CNN
- According to a 2001 study sponsored by 3M, 12 samples of food from around the country tested positive for PFAS chemicals - The Intercept
- Imitation and cultured meats will be the norm by 2040 - TreeHugger
- You May Be Swallowing a Credit Card’s Weight in Plastic Weekly, Says New Study - EcoWatch
- Radiohead Makes Stolen Tracks Available to Help 'Extinction Rebellion' - EcoWatch
- Austria plans to ban glyphosate - GMWatch
Missed some news - Go To Older News
The Journal Evidence-Based Integrative Medicine report "In this commentary, we will discuss how our findings can inform the discussion clinicians have with their patients regarding the ways Mindfulness Based Stress Reduction (MBSR) can relieve back pain. Pain processing is complex and top-down regulation is not fully engaged when pain is treated with pharmacotherapy alone. We share that our study showed a clinically meaningful reduction in pain and improvement in function and discuss some of the possible underlying mechanisms of MBSR’s effect"
The Journal Alternative and Complementary Medicine report "Overall, this study provides support that these formulations appear to be a safe, tolerable, and useful long-term treatment for ADHD, depression, and anxiety, although large-scale inclusive studies are still required. The benefit-to-risk ratio is very favorable in this sample. Routine screening for metabolic and electrolyte abnormalities before commencing treatment and intermittently during follow-up is recommended to detect and mitigate any adverse effects. Our study also suggests that those who have a positive response to micronutrients may sustain these benefits over the longer term."
The Journal Ethnopharmacology report "Acrorus tatarinowii Schott has been widely used in the treatments of neuropsychiatric and digestive disorders in clinical practices of traditional Chinese medicine for thousands of years. Both clinical and preclinical studies demonstrated antidepressant effects of A. tatarinowii. However, the possible action mechanisms of antidepressant effects of A. tatarinowii remain unraveled.........This study first systematically demonstrated the roles of serotonin transporter (SERT) activity in antidepressant effects of 410 A. tatarinowii, including water extract, major fractions and main constituents. These results 411 revealed that A. tatarinowii could regulate SERT activities in bidirectional ways. The SERT 412 activities of major components in water extract of A. tatarinowii provide novel lead compounds for SERT activity compounds, including SERT inhibitors and enhancers"
The Journal Evidence Based Complementary and Alternative Medicine report "This study found a significant positive effect of aromatherapy in reducing pain. These results indicate that aromatherapy should be considered a safe addition to current pain management procedures as no adverse effects were reported in any of the included studies. Additionally, the cost associated with aromatherapy is far less than the cost associated with standard pain management treatment. Although the present meta-analysis indicates a large positive effect for the use of aromatherapy for pain management, the sample size is small. Given the prevalence of aromatherapy, more research is necessary to fully understand clinical applications for its use."
The Journal of Herbal Medicine report "In the light of published data on antidiabetic plants, this review demonstrates that the use of natural medicines can easily become part of the health vernacular. Many medicinal plants are increasingly being utilised to combat diabetes primarily as herbal drugs; others as antioxidants, nutraceuticals, food additives and supplements. Indeed, current research efforts underscore that the use of medicinal plants to control diabetes is no longer in a medical and pharmacological grey area. The use of medicinal plants to manage diabetes is a prelude to a more realistic and more inclusive global health order. Undoubtedly, medicinal plants will increasingly become part of the antidiabetic drug mix. If there is a long-term remedy for diabetes, it must lie in nature's pharmacy of putative antidiabetic agents from plants. While evidence-based phytotherapy for diabetes is finding its voice in the world again, the use of medicinal plants to manage diabetes is a daunting reality as much as it is a bountiful prospect. There is an urgent need to put the use of herbal remedies and other natural products into the correct medical perspective"
The Int Journal of Molecular Science report "Topical applications of plant oils may have different effect on the skin according to their composition and the pathophysiological context of the skin. The composition varies by different extraction methods. When applied topically, constituents of plant oils (triglycerides, phospholipids, FFAs, phenolic compounds and antioxidants) may act synergistically by several mechanisms: (i) promoting skin barrier homeostasis; (ii) antioxidative activities; (iii) anti-inflammatory properties; (iv) direct and indirect (upregulation of antimicrobial peptides) anti-microbial properties; (v) promoting wound healing; and (vi) anti-carcinogenic properties. Future studies can add to current findings to allow for better understanding of these oils, with the potential to develop dermatological treatments and skin care products using these oils."
The Journal Alternative and Complementary Medicine report "Retrospective database analysis demonstrates the potential that acupressure can be an effective, complementary nonpharmacologic tool for relief pain and anxiety with a high degree of participant satisfaction"
The Journal Atherosclerosis report "In conclusion, our findings from this large Japanese cohort supported a significant inverse association between chocolate consumption and risk of developing stroke in women but not in men. However, residual confounding could not be excluded as an alternative explanation for our findings. Sex-specific analysis may be needed in further studies examining the health effect of chocolate consumption"
The Journal Nutrition Research report "In conclusion, chronic proprietary spearmint extract (PSE) supplementation improved scores in 2 domains of attention: complex and sustained. Benefits were also observed during 2 specific tests: the shifting attention test and the 4-part continuous performance test. The present study is the first time that improved attention has been demonstrated after chronic consumption of PSE in young, healthy individuals and provides further support to the body of evidence indicating that PSE is an efficacious nootropic.
The European Journal of Integrative Medicine report "Osteoarthritis (OA) is one of the most common and fast-growing chronic diseases among older adults. The aim of this study was to assess the effect of acupressure therapy on pain, stiffness, and physical functioning of a knee affected by osteoarthritis......Conclusion Acupressure may be an effective intervention for reducing the pain, stiffness, and improving the function of knees with osteoarthritis."
The Journal Evidence Based Complementary and Alternative Medicine report "In conclusion, in this mouse model of bone cancer pain yokukansan (YKS) significantly lessened cancer pain behavior by suppressing MMP-9 expression, suppressing the expression in bone tissue in the early phase and in the spinal cord in the late phase of pain development.
Yokukansan (YKS) is a Japanese herbal medicine consisting of 7 main galenicals, Atractylodes lancea, Poria sclerotium, Cnidium officinale, Angelica acutiloba, Bupleurum falcatum, Glycyrrhiza uralensis, and Uncaria rhynchophylla
The Journal of Ethnopharmacology report "Conclusion The results of this study provide new scientific evidence for the traditional use of local medicinal plant species C. lansium, L. indica, P. bleo, S. crispus, V. amygdalina and V. trifolia in cancer treatment. These results highlight the importance of the upkeep of these indigenous plants in modern society and their relevance as resources for drug discovery."
The American Journal of Psychiatry report "The results of this double-blind randomized placebo controlled trial indicated that administration of 400 mg or 800 mg of CBD reduced cue-induced craving and anxiety in heroin-abstinent individuals, suggesting a potential role for CBD to alleviate clinical signs and symptoms critical to the continued cycle of addiction. The effects of CBD on drug cue–induced craving and anxiety were evident soon after acute exposure to the drug (session 1). In addition, there was a protracted effect on these measures 1 week after short-term repeated administration of CBD (session 4). CBD also tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels that were induced by salient drug cues. Importantly, CBD administration (at 400 mg or 800 mg) was associated with only mild adverse events"
The Journal Evidence Based Complementary and Alternative Medicine report "Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant therapy in clinical use and has been shown to be effective in cancer patients. However, the mechanism of JDTYS is still unclear. Therefore, the aim of the present study is to investigate the chemopreventive effects of JDTYS for esophageal squamous cell carcinoma (ESCC) and to clarify the potential mechanism.....In summary, we provided evidence that JDTYS significantly inhibits the formation of esophageal precancerous lesions induced by NMBA. The inhibitory effect of JDTYS on esophageal precancerous lesions is related to downregulation of proliferation related proteins Ki67 and c-Jun and modulation inflammation related proteins COX-2, NF-κB, PTX3, and CD11B.
The Journal Phytotherapy Research report "In conclusion, the present study shows that the anxiolytic‐like effect of Citrus sinensis essential oil seems to be mediated by the nitrergic system."
The Journal of the National Cancer Institute report "In summary, we found higher vitamin E status, as measured by serum alpha-tocopherol concentrations from two blood collections taken three years apart, were related in a dosedependent manner to decreased lung cancer incidence during a 28-year period. The inverse association was observed primarily among younger men and those with fewer cumulative years of cigarette smoking. Our findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.
The Journal Evidence Based Complementary and Alternative Medicine report "The results of current experiments indicated that wound healing effects of Callicarpa nudiflora water extract (CNE) were quicker and better than Vaseline and Silver sulfadiazine (SSD) in a deep second-degree scald rat model. Macroscopic difference of wound closure in proliferation and tissue remodeling phase suggested a positive effect of CNE on wound closure after 12 days since scald wound induction. The 20% CNE-treated group exhibited structures of epidermis and dermis were well restored with minimum of scars on the last phase of healing."
The Journal Molecular Psychiatry report "Excess oxidative stress is increasingly appreciated to participate in the pathophysiology of brain disorders, and decreases in the major antioxidant, glutathione (GSH), have been reported in multiple studies.....We found that the naturally occurring isothiocyanate sulforaphane increased blood GSH levels in healthy human subjects following 7 days of daily oral administration. In parallel, we explored the potential influence of sulforaphane on brain GSH levels in the anterior cingulate cortex, hippocampus, and thalamus via 7-T magnetic resonance spectroscopy. A significant positive correlation between blood and thalamic GSH post- and pre-sulforaphane treatment ratios was observed, in addition to a consistent increase in brain GSH levels in response to treatment. This clinical pilot study suggests the value of exploring relationships between peripheral GSH and clinical/neuropsychological measures, as well as the influences sulforaphane has on functional measures that are altered in neuropsychiatric disorders.
* Sulforaphane is a natural phytochemical compound abundant in the seeds and sprouts of cruciferous plants such as broccoli.
The Journal Planta Medica report "In this study, wounds treated with Rosehip Oil (RO) healed rapidly and the period of epithelialization time was shortened when compared to that of the control group. Wounds in the RO group showed lower infiltration of inflammatory cells, enhanced proliferation of fibroblasts, collagenation, angiogenesis, and better collagen remodeling (basket weave meshwork of collagen). These provided strong support for the effective healing activity and scar-improving efficacy of RO
The Journal Evidence Based Complementary and Alternative Medicine report "This study demonstrates that a compound of four Chinese herbs, namely, P. lobata (Willd.), S. miltiorrhiza, S. chinensis, and S. marianum, can be a novel therapeutic agent on preventing and reversing Alcoholic Liver Fibrosis (ALF), and the underlying mechanism of the protective effects may involve TGF-β1/Smad signaling pathway.
The Journal Alternative and Complementary Medicine report "Through the analysis of green tea consumption and Coronary Arterial Disease (CAD) related biomarkers, we concluded that a small amount, high-frequency green tea consumption was associated with a reduced risk of CAD in female populations in Guangzhou, China, and the association might be partly due to altered CAD-related biomarkers.
The Journal of Functional Foods report "These findings are consistent with clinical data indicating that elderberry can mitigate the duration and severity of influenza symptoms in patients. The action of elderberry is both direct – suppressing viral entry, affecting the post-infection phase, and viral transmission from cell to cell, and indirect – by modulating the release of cytokines such as IL-6, IL-8, and TNF. These data support the use of Sambucus nigra berries as nutraceutical ingredients for the management of influenza infection.
The American Botanical Council report "Breast cancer is the most common cancer in the United States, with 266,120 cases in women and 2,550 cases in men diagnosed in 2018.The majority of women diagnosed with breast cancer will undergo conventional treatment in the form of surgery, radiation, chemotherapy, and/or endocrine therapy. Many of these women seek additional integrative therapies, including botanicals, to improve their tolerance to, and the efficacy of, these conventional treatments.
While the clinical data supporting the use of botanicals concurrent with conventional treatment is far from robust, there is a body of emerging data. One area of interest is the reduction of adverse side effects, which can make conventional treatment a more tolerable experience and improve treatment adherence, thereby supporting better outcomes. This article provides an overview of the current state of evidence for selected botanicals for improving outcomes with conventional therapies.
The American Journal of Clinical Nutrition report "In this cohort of eastern Finnish middle-aged and older men, a higher ratio of animal to plant protein in the diet and higher meat intake were related to increased mortality risk. Furthermore, higher total protein intake appeared to be associated with increased mortality risk mainly among those with a disease history at baseline. Apart from meat intake, other protein sources—that is, dairy, fish, egg, and plant protein sources—were not associated with mortality risk."
The European Journal of Integrative Medicine report "The application of rose oil aromatherapy by inhalation reduced the scores of preoperative anxiety of patients undergoing septorhinoplasty/rhinoplasty."
The Journal Evidence Based Complementary and Alternative Medicine report "This review found that Cordyceps sinensis could benefit patients with GOLD stage 2 to 3 COPD in terms of exercise tolerance and life quality. It may have a potential effect on improving lung function. Cordyceps sinensisseemed to be beneficial in reducing exacerbation and improving symptoms in stable COPD of GOLD stages 2 to 3 with few adverse events. But we could not draw strong conclusions on effectiveness or safety due to methodological weaknesses and risk of bias of the included studies."
The Journal Alternative and Complementary Medicine report "The results indicated that a combination of Melissa officinalis plus Nepeta menthoides was effective for the treatment of insomnia. The severity of insomnia, total PSQI, sleep latency, daytime dysfunction, and sleep disturbance indicators all decreased in the treatment group, and the sleep efficacy, sleep quality, and sleep duration were increased.
The Journal Military Medical Research report "Our findings have honed the existing knowledge base on therapeutic horseback riding (THR), a beneficial intervention for veterans with PTSD, by identifying a clinically meaningful dosage of THR. A 3-week THR program was effective, and a 6-week program produced clinically significant outcomes in PTSD levels. Older veterans, such as the majority in our sample, may have been diagnosed with PTSD decades ago; THR may be particularly promising for them. It may be important for health systems to recognize such promise by supporting THR as a reimbursable complementary therapy."
The British Journal of Nutrition report "This dietary intervention study in healthy volunteers identified specific effects of dark chocolate on digestive and cerebral function. These findings add to the body of literature indicating that naturally occurring substances in chocolate, in particular cocoa flavanols, in isolation and in combination, have measurable biological effects. Future research will establish if these are clinically relevant. Acute and chronic disturbances in bowel function are common in the community and can be a major burden....If the “nutraceutical” effects of dark chocolate or cocoa-based products are confirmed, then this could be a safe and popular alternative to pharmacological treatment. If, as expected, there are also positive effects on well-being, then the combination of peripheral and central effects could be a much needed, novel approach for the treatment of participants with conditions such as irritable bowel syndrome that are affected by both disorders of digestive function and mood
The Journal of Psychoactive Drugs report "Results indicated that psilocybin enhanced divergent thinking and emotional empathy the morning after use. Enhancements in convergent thinking, valence-specific emotional empathy, and well-being persisted seven days after use. Sub-acute changes in empathy correlated with changes in well-being. The study demonstrates that a single administration of psilocybin in a social setting may be associated with sub-acute enhancement of creative thinking, empathy, and subjective well-being. Future research should test whether these effects contribute to the therapeutic effects in clinical populations."
The Journal Nutrition Research report "RNA-Seq Expression Profiling analyses from a pilot clinical trial in which women with breast cancer consumed 2 ounces of walnuts per day for 2 to 3 weeks between the diagnostic biopsy and subsequent surgery showed that gene expression in the tumor was modified in ways expected to slow proliferation, reduce inflammation, reduce metastasis and to increase cancer cell death. It seems likely that if gene expression was modified in the tumor due to consumption of walnuts, then gene expression of any metastatic cells should also be modified thus decreasing risk for cancer recurrence."
The Journal Integrative Medicine report "Complementary and alternative medicine treatment for insomnia has been sought due to the possible adverse effects of conventional pharmacotherapies. We performed a preliminary evaluation of the feasibility of using, and of the effect of a herbal tea (HT002), based on Traditional East Asian Medicine, in mild-to-moderate insomnia.
In conclusion, the preliminary results of the current protocol suggest that 4-week treatment with HT002 may reduce the severity of insomnia symptoms and improve the quality of life."
The Journal Clinical Nutrition report "There is a large body of evidence which supports the role of inflammation in the pathophysiology of mental health disorders, including depression. Dietary patterns have been shown to modulate the inflammatory state, thus highlighting their potential as a therapeutic tool in disorders with an inflammatory basis....These results provide an association between pro-inflammatory diet and risk of depression. Thus, adopting an anti-inflammatory diet may be an effective intervention or preventative means of reducing depression risk and symptoms
The Journal of Child and Adolescent Psychopharmacology report "This study provides evidence for satisfactory outcomes with saffron in treatment of ADHD. In this double-blind randomized trial of C. sativus versus methylphenidate in treatment of ADHD, C. sativus was as effective as methylphenidate. The clinical relevance of these findings was emphasized by improvements seen in both Parent and Teacher Rating Scale scores. Also C. sativus was safe and showed equally or lesser adverse effects.
The Journal Alternative and Complementary Medicine report "This study aimed at identifying areas of consensus among naturopathic experts in IBS. Panelists reached consensus on a 45-item list of reasonable naturopathic approaches for IBS in North America. Consensus was reached in the domains of general approaches to IBS, office visits, tracking progress, testing, interventions, and resources. It is our intention that these results will inform protocol development in future randomized controlled trials. We believe that there is opportunity for future refinement of these consensus guidelines, reflecting an evolving field of evidence-informed practice of naturopathic medicine."
The Journal Complementary and Alternative Medicine report "E-Zhu (Curcuma zedoaria) is known as a classical traditional Chinese medicine and widely used in the treatment of cancers, cardiovascular disease, inflammation, and other diseases. Its main components include curcumol and curcumin, which have anti-inflammatory and antifibrosis effects.
In conclusion, our findings perfectly supported the hypothesis demonstrated that curcumol and curcumin could reduce the expressions of inflammatory factors by inhibiting the NF-κB signaling pathway and TGF-β1/Smads signaling pathway.
The Journal Complementary and Alternative Medicine report " this review included a summary of the data published by many researchers related to the protective and/or treatment role that propolis and/or its active ingredients play against gastrointestinal associated disorders that affect humans. The focus was on the following: oral mucositis, ulcerative colitis, gastrointestinal cancers, and gastric ulcers. Analysis of the published work indicated that the efficacy of propolis in the treatment of gastrointestinal disorders could be attributed to its antioxidants and anti-inflammatory properties.
The Journal Alternative and Complementary and Alternative Medicine report "Despite widespread use, there remains a paucity of research exploring cancer patients’ experiences of receiving complementary therapy treatment. We wanted to gain insight into the experiences of patients using a complementary therapy outpatient service offering aromatherapy, massage, reflexology and Reiki....Qualitative comments collected from this evaluation indicate that complementary therapies can address both physical and emotional concerns often simultaneously and provide a unique therapeutic space for patients. Many patients have not had this experience before and this may introduce them to new methods of addressing complex multi dimensional issues resulting from living with a cancer diagnosis."
The Journal Alternative and Complementary Medicine report "Geriatric depression is a major public health problem in China. The study compared the intervention and follow-up effects of aromatherapy massage and inhalation on symptoms of depression in community-dwelling older adults after an 8-week intervention.
Conclusion: Both aromatherapy massage and aromatherapy inhalation may have important implications for intervening depression in older adults
The Intl Journal. Environ Res. Public Health report "Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. .... The results indicate that the 5% concentration of Cayenne pepper in the preparation of CPC is the best choice, since no additional effects can be obtained with the 10% concentration, and the effects are higher than those observed at the 2.5% concentration. Importantly, 5% CPC application did not induce a significant increase of inflammatory-related biomarkers, suggesting that 20-min application has no negative side effects at systemic levels
The Int. J. Environ. Res. Public Health report "The aim of this study was to examine the relationship between estimated residential exposure to agricultural chemical application and premature mortality from Parkinson’s disease (PD) in Washington State....The relationship between pesticide exposure and premature mortality aligns with previous biological, toxicological, and epidemiological findings. Glyphosate, the world’s most heavily applied herbicide, and an active ingredient in Roundup® and Paraquat, a toxic herbicide, has shown to be associated with the odds of premature mortality from PD.
The University of Illinois at Chicago via NewsWise report "A growing body of evidence supports the idea that alcohol exposure early in life has lasting effects on the brain and increases the risk of psychological problems in adulthood. Now, researchers at the University of Illinois at Chicago have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming."
The Ramazzini Institute via GMWatch report "Global Glyphosate Study pilot phase shows reproductive and developmental effects at "safe" dose"
A new study has found that exposure to glyphosate-based herbicides (GBHs), including Roundup, caused reproductive and developmental effects in both male and female rats, at a dose level currently considered safe in the US (1.75 mg/kg bw/day). Exposure to GBHs was associated with androgen-like effects, including a statistically significant increase of anogenital distance (AGD) in males and females, delay of first estrus, and increased testosterone in females, in the study conducted by scientists at the Ramazzini Institute, Bologna, Italy.
The Journal Cognitive Behaviour Therapy report "To our knowledge, this is the first meta-analysis to examine the efficacy of Mindfulness Based Cognitive Therapy (MBCT) specifically for patients who are currently experiencing depressive symptoms....Given that MBCT may be of similar efficacy to other active therapies for currently depressed individuals, further research could continue to examine the efficacy of MBCT in other psychiatric conditions (e.g. anxiety disorders).
The European Journal of Integrative Medicine report "Overall, present study suggest that the selected plants such as Cassia occidentalis, Callistemon viminalis, Cleome viscosa and Mimosa hamataexhibited significant cytotoxicity against MCF-7 breast cancer cells along with inhibition of angiogenesis in CAM model and scavenging of free radicals.
The American Academy of Neurology via Newswise report " For people with multiple sclerosis (MS), drinking around 290 calories per day of soda or other sugar-sweetened beverages, or the equivalent of about two cans of non-diet soda, may be tied to more severe symptoms and a higher level of disability compared to people with MS who seldom consume sugar-sweetened beverages, according to a preliminary study."
The Journal Parkinsons Disease report "Aerobic exercise tended to best improve memory in individuals with Parkinsons Disease (PD). Further, exercise in general appears to be associated with improved cognitive function in individuals with PD. However, improvements might be limited to certain cognitive domains (global cognitive function, executive function or memory). Besides cognitive function, exercise, regardless of mode, tended to slow disease progression in individuals with PD
The Journal Molecules report "Obesity is a common but often underrated condition that is globally considered to be a major public health concern that contributes significantly to the rate of morbidity and death. This review has shown the effectiveness of Hibiscus sabdariffa extract (HSE) on obesity-related parameters according to different experimental designs employed in various studies reviewed. Results have consistently reported that HSE consumption reduces body weight, lipid accumulation and total cholesterol metabolism in both animal and human studies. Its effectiveness in inhibiting pancreatic lipase and on adipocyte differentiation has also been frequently reported, thus confirming its therapeutic potential in obesity management. H. sabdariffa extracts are generally considered to have a low degree of toxicity. However, some studies revealed that H. sabdariffa consumption at high doses may have some adverse effects. Hence more animal and clinical studies are required to determine safe doses of H. sabdariffa to balance the therapeutic and toxicological effects
The Iranian Journal of Basic Medical Science report "Chronic neuropathic pain is a common significant and debilitating problem that presents a major challenge to health-care. Despite the large number of available drugs, there are no curative conventional treatments for neuropathic pain. Nowadays, more attention has been focused on the herbal formulation in the field of drug discovery. Therefore, we performed an extensive review about herbal drugs and plants that exhibited protective effects on neuropathic pain... The more common plants which are used for the treatment of neuropathic pain are included as: Acorus calamus, Artemisia dracunculus, Butea monosperma, Citrullus colocynthis, Curcuma longa, Crocus sativus, Elaeagnus angustifolia, Ginkgo biloba, Mitragyna speciosa, Momordica charantia, Nigella sativa, Ocimum sanctum, Phyllanthus amarus, Pterodon pubescens Benth, Rubia cordifolia and Salvia officinalis...
In conclusion, this review suggests that some herbal plants can be suitable candidates for the treatment of neuropathic pain.
The Journal of the American College of Nutrition report "This study evaluated the effect of cinnamon on disease activity, serum levels of some inflammatory markers, and cardiovascular risk factors in women with rheumatoid arthritis (RA)
In conclusion, this study demonstrates the beneficial effect of cinnamon supplement on the improvement of disease activity and inflammatory biomarkers in RA. The findings indicated that the administration of cinnamon at 2000 mg/d for 8 weeks resulted in a significant reduction in serum TNF-a, CRP, tender and swollen joints count, and blood pressure in women with RA. Regarding the availability and lack of side effects, the regular intake of cinnamon supplement may be used as a pharmacological agent in the treatment of RA.
The Journal Chinese Medicine report "Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely Andrographis paniculata, Acanthopanax senticosus, Camellia sinensis, and Hedyotis diffusa were eventually selected to form an innovative herbal formula.
In summary, our innovative Chinese herbal formula was demonstrated to possess anti-tumor, anti-metastatic and bone-protective activities in metastatic breast tumor-bearing mice. The preclinical data generated in this study would lead to the development of evidence-based supplement as adjuvant therapy for metastatic breast cancer.
The Journal Phytherapy Research report "Of the phytomedicines reviewed, P. methysticum (Kava) has the largest evidence base for use in the anxiety disorders, with tripartite level of support from in vitro, in vivo, and human clinical studies. Thus, P. methysticum remains the hallmark anxiolytic phytomedicine (minor concerns over liver toxicity notwithstanding). It is the most strongly evidenced for generalised anxiety, with clinical investigations now examining GABA metabolite changes via neuroimaging, and whether individual gene differences in GABA pathway polymorphisms influence treatment response. V. officinalis, C. asiatica, M. recutita, G. biloba, P. incarnata, and W. somnifera offer the next most extensive evidence for reducing anxiety through GABA‐related pathways; all with preclinical studies of GABA‐ergic action in rodent animal models, with human studies
The Journal Food and Function report "The present meta-analysis showed that consumption of apples and pears was significantly associated with decreased risk of Type 2 Diabetes Mellitus (T2DM). Furthermore, dose–response analysis indicated that apple and pear consumption was inversely associated with T2DM risk in a dose-dependent trend
The Journal Nature report "Sleep is integral to life. Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease2, we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice."
The Journal Neurology, Neurosurgery & psychiatry report "Our findings suggest that MS patients with allergies have more active disease than those without allergies, and that this effect is driven by food allergies. We showed that patients with food allergy have a 1.3 times significantly higher rate for cumulative number of attacks compared with patients with no allergies, along with a 2.5 times higher likelihood of having a Gad-enhancing lesion on brain MRI. The environmental allergy and drug allergy groups did not show major differences when compared with the group with no reported allergies"
The Journal Pain report "The present study shows that mindful individuals are less sensitive to pain and exhibit significantly lower activation in the precuneus/dPCC, central nodes of self-referential and nociceptive processing.... These findings could be utilized to better develop adjunctive pain therapies (biofeedback; mindfulness meditation; dialectical behavioral therapy) to specifically target increases in trait mindfulness and reductions in PCC/precuneus activity to treat pain.
The Journal Nutrients report "Evidence from published reports is reasonably strong to indicate that consumption of cherries decreased markers for oxidative stress, inflammation, exercise-induced muscle soreness and loss of strength, and blood pressure acutely after ingesting cherries. Limited numbers of published reports also indicate beneficial effects of consuming cherries on arthritis, diabetes, blood lipids, sleep, cognitive functions, and possibly mood. It should be noted that many of these studies, which suggested health benefits of cherry consumption, used amounts (45–270 cherries/day) that might be considered to be a high dose."
The Journal Evidence Based Complementary and Alternative Medicine report " Sleep plays an important role in individuals’ health. The functions of the brain, the cardiovascular system, the immune system, and the metabolic system are closely associated with sleep. As a prevalent sleep disorder, insomnia has been closely concerned, and it is necessary to find effective therapies. In recent years, a growing body of studies has shown that mind-body therapies (MBTs) can improve sleep quality and ameliorate insomnia severity.....MBTs can be effective in treating insomnia and improving sleep quality for healthy individuals and clinical patients.
Restorative Neurology and Neuroscience report "Yoga, a mind body intervention re-established immunological tolerance by aiding remission at molecular and cellular level along with significant reduction in depression. Thus in this inflammatory arthritis with a major psychosomatic component, yoga can be used as a complementary/adjunct therapy."
Avicenna Journal of Phytomedicine report ":Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice....Administration of crocin reduced d-galactose-induced aging in mice through inhibition of oxidative stress, reduction of inflammation and elevation of sex hormones"
Avicenna Journal of Phytomedicine report "Saffron has beneficial effects on depression and homocysteine level in patients with major depression."
The Journal Cannabis and Cannabinoid Research report "Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, and new therapeutic strategies are still required. Here we screened a synthetic cannabinoid library to identify compounds that uniformly reduce the viability of seven CRC cell lines......We identified three families of cannabinoid compounds that reduce CRC cell viability through a noncanonical receptor mechanism. Future modification of these compounds may lead to the development of novel therapies to treat this disease."
The Journal Environmental Research report "An organic diet was associated with significant reductions in urinary excretion of several pesticide metabolites and parent compounds. This study adds to a growing body of literature indicating that an organic diet may reduce exposure to a range of pesticides in children and adults. Additional research is needed to evaluate dietary exposure to neonicotinoids, which are now the most widely used class of insecticides in the world."
The American Journal of Physiology—Renal Physiology report "Zinc deficiency (ZnD) is implicated in hypertension, in part, by promoting cardiovascular and renal 224 dysfunction. However, a direct link had not been established. In this study, we directly explored the role of Zn2+ 225 bioavailability in Blood Pressure (BP) regulation. Using both in vivo and in vitro models of ZnD, our novel findings indicated that 1) Zn2+ contributes to BP regulation via modulating renal Na+ 226 transport, 2) renal NCC mediates ZnD-induced hypertension and 3) NCC is a Zn2+ 227 -regulated transporter that is 228 upregulated by ZnD"
Environmental Health News report "Kids exposed to phthalates prenatally and as 3-year-olds have decreased motor skills later in their childhood, according to a new study.The study is concerning because phthalates are so widely used. Previous research found that phthalate exposure is linked to decreased motor skills for infants and toddlers but this is the first study to suggest these problems may persist as the children age.
"As lower scores on measures of motor development have been associated with more problems in cognitive, socioemotional functioning and behavior, the findings of this study have implications related to overall child development," the researchers wrote in the study published online in Environmental Research.
The Journal Alternative and Complementary Medicine report "Administration of oral Cannabidiol (CBD) in addition to routine psychiatric care was associated with post-traumatic stress disorder (PTSD) symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD
The Journal lanta Medica report "Licorice has been traditionally recognized as a “guide drug” (drugs that enhance the effectiveness and reduce the toxicity of other ingredients) and is added to most traditional and modern prescriptions. Basic in vitro and in vivo pharmacological studies indicate that the combined treatment of licorice compounds, such as GA, ISLG, and LCA, with clinical chemotherapy drugs presents both synergistic antineoplastic effects and a reduction of the side effects of chemotherapeutics GL also reverses cisplatin resistance in hepatocellular carcinoma cells. Furthermore, GL pretreatment enhances UVB-induced apoptosis in melanoma cells, blocks UVB-induced skin tumor formation, and hinders ionizing radiation-induced tumor cell extravasation and lung metastasis. All of these findings indicate that a combined therapy may provide an optimal venue for licorice compounds in clinical application."
The Avicenna Journal of Phytomedicine report "In conclusion, our study showed that hydro alcoholic extract of UD prevents establishment of atherosclerotic lesions in rat aorta, which is associated with positive effects on serum lipid profile without significantly affecting antioxidant status."
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