My name is Laura Murphy, I am a Biologist and a practitioner of Natural Medicine, I am a qualified Naturopath, Homeopath, Herbalist and Nutritionist. I am passionate about natural medicine and spend innumerable hours researching evidence based natural therapies and disease and rather than hoard all this valuable information on my computer, I decided to set up this humble website. If you have any questions or suggestions please "contact me"
Look to your health; and if you have it, praise God, and value it next to a good conscience; for health is the second blessing that we mortals are capable of; a blessing that money cannot buy - Izaak Walton
Look to your health; and if you have it, praise God, and value it next to a good conscience; for health is the second blessing that we mortals are capable of; a blessing that money cannot buy - Izaak Walton
PETITION - Free Julian Assange, before it's too late. Sign to STOP the USA Extradition
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- The World’s Most Important Political Prisoner - Consortium News
- Vaccine Mandates for Everyone, Everywhere—A Globally Coordinated Agenda - Children's Health Defense
- Seize some seeds from the garden for planting next year - PhysOrg
- Why red meat raises your cancer risk - Mother Nature Network
- Antibiotic Resistance Surges in Dolphins, Mirroring Humans - NewsWise
- State AGs promise bankruptcy court showdown as Purdue inks $10B opioid settlement - Fierce Pharma
- Dangerous levels of plastic found in children’s bodies finds new study - Nation of change
Missed some news - Go To Older News
The Journal Phytomedicine report "Numerous studies have focused on solvent extracts from locust trees (Gleditsia spp.), which contain diverse bioactive components including saponins, flavonoids, and alkaloids. However, because of the undefined nature of such phytochemicals, their clinical application as chemotherapeutic agents has often been limited. This study aimed to evaluate the anti-oncogenic activity of triacanthine, an alkaloid obtained from Gleditsia triacanthos L.Triacanthine inhibits the proliferation, migration, and invasion of bladder-carcinoma cells both in vitro and in xenografted tumors. Unlike cisplatin, which caused a significant loss of body weight, triacanthine had no side effects at doses of up to 10 mg/kg in xenografted mice. Moreover, an acutetoxicity test showed no harmful effects in triacanthine-treated mice. We believe that our results provide valuable information about triacanthine, thereby potentially enhancing the development of chemotherapeutic agents (without side effects) for patients with bladder cancer.
The Journal Epilepsy & Behaviour report "High-dose oral Vitamin D3, 5000 IU/day was safe and well tolerated in subjects with epilepsy. Vitamin D levels increased significantly at 6 and 12 weeks but never exceeded potentially toxic levels, defined as >100 ng/ml. To reduce variability, we will now recruit subjects who only have three or more seizures per month.
The Journal Aging reports "Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation"
Anti-inflammatory, Antimicrobial, Anticancer and Carcinogenic Prevention + Dandelion / Taraxacum officinale
The Asian Journal of Pharmaceutical Research and Development report "According to the contextualization of articles and dissertations used as basis for this study, it can be suggested that the plant of the species Taraxacum officinale expresses great importance for the advances in phytotherapy medicine, bringing to the fore pharmacological actions of an anti-inflammatory,
and antimicrobial, anticancer and carcinogenic prevention.It is possible to observe that the leaf and root of Taraxacum officinale has an anti-inflammatory, anticancer and antimicrobial action that is more significant than the flower of this species."
Seminars in Cancer Biology report " Restoring vitamin C to the normal range in cancer patients is a straightforward strategy that may improve the response to epigenetic therapy. This may enhance disease control and, in younger patients, enable subsequent curative treatment such as transplantation and prolonged survival. Vitamin C supplementation may also increase the catalytic activity of other epigenetic regulators such as histone demethylases, for which new drugs are currently being developed. Because aberrant epigenetic regulation is common to all cancers, the basic effects of vitamin C on the methylation of DNA and histones may have implications far beyond hematological cancers"
The Journal Herbal Medicine report "This review identified moderate quality evidence to suggest that standardised aged garlic extracts are likely to be effective as an adjunct therapy to the standard treatment of hypertension in patient populations with SBP > 140 mmHg. The quality of evidence for the role of garlic in the management of dyslipidaemia is currently low.
The Journal of Traditional and Complementary Medicine report "In this article effort has been made to discuss available pharmacological findings that have been frequently reported for S. officinalis. On the basis of the available literature evidence, this plant shows anticancer, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, hypoglycemic, hypolipidemic, and memory-enhancing effects. The effectiveness of S. officinalis as an antinociceptive, hypolipidemic, and memory-enhancing medicinal plant has been confirmed with clinical trials. In addition to the above mentioned effects, a number of other biological actions such as activating benzodiazepine receptors and inhibiting pentylenetetrazole-induced seizure have been shown for S. officinalis in literature"
The Journal Chinese Medicine report "Despite its limitations, this study provides powerful and preliminary data to support the future evaluation of Radix Salviae Miltiorrhizae (RSM) in hepatocellular carcinoma (HCC). RSM may be a potential anti-HCC inhibitor, which can be developed as a therapeutic option for the treatment of cancer."
The Journal JAMA Internal Medicine report "This study found that consumption of total, sugar-sweetened, and artificially sweetened soft drinks was positively associated with all-cause deaths in this large European cohort; the results are supportive of public health campaigns aimed at limiting the consumption of soft drinks."
The Journal Evidence Based Complementary and Alternative Medicine report "Results from these studies are promising and suggest that Cannabidiol (CBD) may have a role in the development of new therapeutic strategies in mental diseases, and they justify an in-depth commitment in this field. However, clinical evidence we show for CBD in psychiatric patients is instead still poor and limited to schizophrenia and anxiety, and it needs to be implemented with further studies carried out on psychiatric patients."
The Journal Alternative and Complementary Medicine report "The statistical and clinically significant improvements in all outcome measures of pain, physical function, and disease assessment suggest that purified honey bee (Apis mellifera) venom (HBV) injections may offer a potential treatment for patients with knee pain from Osteoarthritis (OA) who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics, for example, acetaminophen.
The Journal PLOSOne report "It has been suggested that music can provide a low cost, non-pharmaceutical option for populations suffering from sleep difficulties . The present study aimed to investigate this by gathering data from a general population recruited via self-selection online and through university advertisements without constraint.... Music’s potential for successful use in therapeutic and clinical settings makes it a viable, low cost, side-effect free option in the treatment of sleep loss. The results of this population survey suggest that many individuals are already intuitively using diverse types of music to fight sleep difficulties. Based on the cascade of potential factors that influence music choices that we have identified (body and brain mechanisms linked to anxiolytic properties of music, personal preference, demographic factors) and, in particular, the wide range of reasons we identified that drive music’s potential to improve sleep in different circumstances, future studies can investigate how various flexible and personalized music interventions can be developed to best target the various causes of sleep loss."
The Journal Evidence-Based Complementary and Atlernative Medicine report "In this study, an increased brain uptake of Tryptophan (Trp) and a shifted Trp metabolism were identified as the underlying mechanisms of the beneficial effects of moxibustion treatment on depression-like behavior. The influence of therapeutic duration and extent on antidepressant effect was related to Trp transport and metabolism in the hippocampus. A prolonged therapeutic duration improved both Trp transport and metabolism to achieve a better antidepressant effect. As a more sensitive factor, therapeutic extent exerted a nonlinear influence on Trp transport. Further studies are needed to determine the optimal therapeutic extent for superior anti-depression moxibustion therapy."
The Journal Complementary Therapies in Medicine report "Safety, efficacy, tolerability, and symptom relief were considerable in fig fruit extract in comparison with hydrocortisone 1.0%. This clinical trial suggests that fig fruit extract can be used instead of low potent corticosteroid in mild to moderate cases of Atopic Dermatitis
The Physiological Society report "This study was the first to demonstrate relationships between objective indicators of unhealthy diet and subsequent changes in depressive symptoms in youth. These results add to the growing literature on the role of diet in adolescent depression (Jacka et al., 2011; Khalid et al., 2016; Jacka et al., 2017). The fact that sodium excretion was related to depressive symptoms at follow‐up, but not at baseline, suggests that the effects of sodium on mood may accumulate over time, although replication of these results in other cohorts will be important. Interestingly, potassium excretion was not correlated with depressive symptoms, but emerged as a significant predictor when modeled together with sodium excretion. These results suggest that it is the unique combination of high sodium and low potassium intake that is most predictive of increased adolescent depression."
The Journal Phytomedicine report "With the deep analysis of molecular mechanism of Astragalus membranaceus (AM) and Panax ginseng (PG) in immune regulation, a clear result was obtained that AM and PG had the accurate, broad and comprehensive strategy in regulating human immune system. We speculate that the combination of these two tonic drugs should more effective treatment than the use of single drug in immunosuppression models. That meaningful work could contribute to the interpretation of compatibility of TCM prescriptions. Besides, nervous system was seen to have a close relationship with immune system in this our experiment and many literatures also demonstrated this relationship (Aliev, 1962; Rabin et al., 1988; Sierra Vazquez et al., 1998; Webb and Smith, 1966). So, a deeper insight into enzymatic network around AM and PG will provide us a better evidence of the mechanism of immune regulation, such as reaction site, enzyme activity and its products. In this way, new sight of targets seeking and validation in immune therapy is found and suitable for other systemic disorders.
The Journal of Nutritional Science report "In conclusion, we provided first evidence that coffee consumption reduces HFD-induced liver damage by modulating pathways involved in the gut–liver axis. Coffee reduced the HFD-induced liver steatosis and metabolic derangement by: Reducing hepatic fat deposition possibly through increased fat oxidation in the liver; Increasing cholesterol intestinal efflux; Reducing lipid digestion and ameliorating the intestinal system involved in lipid sensing and energy metabolism regulation, and Ameliorating gut barrier function through a restoration of tight junction proteins in the duodenum and colon.All these mechanisms were accompanied by a negligible change in gut microbiota composition
The Journal of Alternative and Complementary Medicine report "As the current study results indicate the effectiveness of inhalation aromatherapy with Citrus aurantium (neroli oil) (CA) flower essential oil, it may be beneficial as an anxiolytic treatment for acute coronary syndrome (ACS) patients. Considering the high prevalence and importance of anxiety among these patients and necessity of its management, this simple and efficient nursing intervention may be a valuable and important solution. Thus, it may be recommended that aromatherapy with CA essential oil be included in the nursing program of Coronary Care Unit (CCU) patients
The Journal Gastrointestin Liver Disease report "The present study shows that the administration of a 30- day course of a novel oral combination of two nutraceutical compounds, namely curcumin and fennel oil, results in early and consistent symptomatic relief in IBS patients with both subtypes. The benefit is achieved without safety and tolerability concerns. Further studies should target subpopulations of IBS patients while identifying the ideal treatment periods."
The Journal Clinics in Dermatology report "Complementary and alternative medicine approaches are popular among some patient segments due to the perception that they are "natural" and thus are believed to be less likely to be dangerous, to be less toxic, or to cause fewer side effects. In dermatology, these can include aromatherapy, botanicals, and essential oils (plant extracts). Preliminary evidence, biological activity studies, and small pilot clinical trials conducted outside of North America, mostly in young adults, suggest that some may have value in acne treatment. "
The Journal Evidence Based Complementary and Alternative Medicine report "Treatment with gingerols fractions (GF) and vitamin D for two weeks significantly improves delayed diabetic wound healing. The data showed that vitamin D and gingerol activate vascularization, fibrin deposition (HPX, FN, and collagen), and myofibroblasts in such manner to synthesize new tissues and help in the scar formation"
The Journal Planta Medica report "In conclusion, Silymarin-enriched extract (SEE) extract and its bioactive compounds have an antiproliferative effect against human prostate cancer cells (PC-3) cells and also exert an additive effect when combined with Doxorubicin (DXR). Even though the combinational scheme of DXR‑SEE enhances the DXR induced protective autophagy in its initiative steps, it finally suppresses the autophagolysosome degradation, leading to an excessive cell death through the induction of apoptosis; however, more studies are needed to further clarify how these alterations of the autophagic potential serve as a death signal. Since SEE extract highly sensitizes DXRmediated cytotoxicity in PC-3 cells, it gathers the scientific interest regarding its potential application as an adjuvant PCa treatment.
The British Journal of Nutrition report "The review indicates that POM has the potential to enhance endurance and strength performance and to expedite post-exercise recovery by conferring antioxidant and antiinflammatory effects and improving cardiovascular responses during and following exercise. However, positive effects of Pomegranate (POM) supplementation are more likely when POMj contains >0·7 g total polyphenols/0·5 litre, when large muscle mass exercise is engaged and when POMj is ingested at least 60 min before exercise. Therefore, the inclusion (750 ml/d) of polyphenol-rich POM in the diet of active people prior (60 min) and after exercise (during 48 h) could be beneficial for their physical performance and muscle recovery during and following the physical tasks. However, further research is required to assess how chronic POM supplementation impacts the physiological and performance adaptations to exercise training to help optimise POM supplementation guidelines for a range of exercise setting"
The Journal Complementary Therapies in Medicine report "In conclusion, Tai Chi was significantly effective in the management of FM-related syndromes, such as pain, sleep, depression, and fatigue, and consequently reduced the total FIQ score. This review recommends Tai Chi as an alternative to standard care for Fibromyalgia (FM) patients. Further conclusions regarding the effectiveness of Tai Chi compared with conventional therapeutic exercises such as aerobic exercise cannot be firmly drawn due to limited evidence."
The Journal Explore report "Consumption of flixweed or fig, compared to a control group, caused a significant improvement in Irritable Bowel Syndrome (IBS) symptoms including frequency of pain, distention, frequency of defecation and hard stool. Also, the findings showed a significant increase in quality of life, as well as satisfaction with overall bowel habits. However, flixweed and fig intake had no significant effects on abdominal pain severity and C-reactive protein levels."
The Journal Nutrients report "In conclusion, soybean-derived isoflavone glycosides (SIF) showed effectiveness in reducing inflammatory responses in vivo and in vitro. Our study demonstrated the inhibitory effects of SIF on the physiological and histological inflammatory response in DSS-induced colitis in vivo and SIF inhibited the activation of macrophages due to its suppression of NF-kB activation in LPS-stimulated RAW264.7 macrophages in vitro. Our findings suggested that SIF is a potential therapeutic compound and/or functional dietary supplement to prevent inflammatory-related diseases including Inflammatory bowel diseases (IBDs)"
The Journal Phytotherapy Research report "In summary, saffron and its components show significant pharmacological properties and could exert potential therapeutic effects in a wide spectrum of diseases, such as depression, atherosclerosis, diabetes mellitus, neurodegenerative diseases, cancer, and sexual dysfunction. Despite there being promising preclinical results, further investigations are necessary to confirm the effective use of “Red Gold” and its possible applications in clinics"
The Journal Evidence Based Integrative Medicine report "Conclusions. All participants’ microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects."
The Journal Circulation report "In summary, we found that greater intake of sugar-sweetened beverages (SSBs) was associated with a higher risk of mortality and showed a graded association with dose. Intake of artificially sweetened beverages (ASBs) was associated with total and CVD mortality at high intake levels mostly among women and warrants further confirmation. Replacing SSBs with ASBs was associated with a moderately lower risk of mortality. Our results support recommendations and policies to limit intake of SSBs and to consume ASBs in moderation to improve overall health and longevity.
The Journal Evidence Based Complementary and Alternative Medicine report "In conclusion, this study provided a holistic view in the molecular mechanism of Panx Ginseng (PG) enhancing the macrophage phagocytosis with the combination of metabolomics and network pharmacology analyses. Our results also indicated that PG may primarily skew the macrophages to the M2 phenotype by regulating the glutathione and choline metabolism. These findings will help us to take more insight into the immunoregulatory effects of PG. Further studies will evaluate and validate the efficiency of the main targets and constituents of PG in our study."
The Journal Complementary Therapies in Medicine report "Wound covering with Medical Grade Honey (MGH) prevents pathogen infiltration and has antimicrobial activity. Moreover, MGH keeps the wound moist and possesses strong pro-healing effects, such as autolytic debridement of non-vital tissue and restoration of vascular structures. The anti-inflammatory and anti-oxidative action of MGH together with the supplemented vitamins C and E may inhibit scar formation."
The Journal Evidence Based Integrative Medicine report "This study adds to the evidence base for Emotional Freedom Technique (EFT) as an effective mental health intervention, as has been demonstrated in many previous studies. It also suggests that EFT simultaneously improves a broad range of health markers across multiple physiological systems. As hypothesized, participants experienced significant decreases in pain, anxiety, depression, and PTSD. Physiological indicators of health such as RHR, BP, and cortisol also significantly decreased, indicating improvement. Happiness levels increased as did immune system function."
The Journal Medical Sciences report "The effect of the gut microbiome on MS pathology is a promising avenue of investigation. Therefore, characterizing the microbial profile of the MS gut as compared to healthy gut microbiomes, as well as other autoimmune diseases could be insightful. By investigating the structure of these microbiomes, it is possible to understand what microbes are contributing to the pro-inflammatory state and lack of anti-inflammation. From this data, it would be possible to then develop probiotic mixtures containing critical bacterial populations which can increase the number of Tregs as they are diminished in the MS gut microbiome."
The Journal Nutrients report "Nature has provided us with many substances displaying anticancer activity which have widely been applied in medicine, such as taxanes, vinca alkaloids, podophyllotoxin, camptothecin, anthracyclines, their derivatives and others. In recent years, a vast number of natural compounds have been tested to establish their medical potential in cancer therapy; however, only a small minority of these substances have qualified for clinical trials and treatment of cancer patients......Natural compounds remain an interesting tool in cancer treatment, thus we believe that more promising anticancer substances will be discovered which will allow for untapped scientific possibilities."
The American Journal of Phytomedician and Clinical Therapeutics report "The data presented here are in agreement with the use of curcumin herbal supplementation in the human diet and encourages the use of curcumin-phospholipid complex to increase its bioavailability in the body. Thus, it should be considered taking Curcumin- Phospholipid Complex formulations like BCE instead of curcumin alone. This may help efficiently reduce inflammatory processes in the digestive system and thus prevent neurological disorders, since there is an association between chronic gastrointestinal inflammation and increased risk of neurological diseases like Alzheimer and Parkinson’s disease."
The Journal Evidence-Based Integrative Medicine report "In this commentary, we will discuss how our findings can inform the discussion clinicians have with their patients regarding the ways Mindfulness Based Stress Reduction (MBSR) can relieve back pain. Pain processing is complex and top-down regulation is not fully engaged when pain is treated with pharmacotherapy alone. We share that our study showed a clinically meaningful reduction in pain and improvement in function and discuss some of the possible underlying mechanisms of MBSR’s effect"
The Journal Alternative and Complementary Medicine report "Overall, this study provides support that these formulations appear to be a safe, tolerable, and useful long-term treatment for ADHD, depression, and anxiety, although large-scale inclusive studies are still required. The benefit-to-risk ratio is very favorable in this sample. Routine screening for metabolic and electrolyte abnormalities before commencing treatment and intermittently during follow-up is recommended to detect and mitigate any adverse effects. Our study also suggests that those who have a positive response to micronutrients may sustain these benefits over the longer term."
The Journal Ethnopharmacology report "Acrorus tatarinowii Schott has been widely used in the treatments of neuropsychiatric and digestive disorders in clinical practices of traditional Chinese medicine for thousands of years. Both clinical and preclinical studies demonstrated antidepressant effects of A. tatarinowii. However, the possible action mechanisms of antidepressant effects of A. tatarinowii remain unraveled.........This study first systematically demonstrated the roles of serotonin transporter (SERT) activity in antidepressant effects of 410 A. tatarinowii, including water extract, major fractions and main constituents. These results 411 revealed that A. tatarinowii could regulate SERT activities in bidirectional ways. The SERT 412 activities of major components in water extract of A. tatarinowii provide novel lead compounds for SERT activity compounds, including SERT inhibitors and enhancers"
The Journal Evidence Based Complementary and Alternative Medicine report "This study found a significant positive effect of aromatherapy in reducing pain. These results indicate that aromatherapy should be considered a safe addition to current pain management procedures as no adverse effects were reported in any of the included studies. Additionally, the cost associated with aromatherapy is far less than the cost associated with standard pain management treatment. Although the present meta-analysis indicates a large positive effect for the use of aromatherapy for pain management, the sample size is small. Given the prevalence of aromatherapy, more research is necessary to fully understand clinical applications for its use."
The Journal of Herbal Medicine report "In the light of published data on antidiabetic plants, this review demonstrates that the use of natural medicines can easily become part of the health vernacular. Many medicinal plants are increasingly being utilised to combat diabetes primarily as herbal drugs; others as antioxidants, nutraceuticals, food additives and supplements. Indeed, current research efforts underscore that the use of medicinal plants to control diabetes is no longer in a medical and pharmacological grey area. The use of medicinal plants to manage diabetes is a prelude to a more realistic and more inclusive global health order. Undoubtedly, medicinal plants will increasingly become part of the antidiabetic drug mix. If there is a long-term remedy for diabetes, it must lie in nature's pharmacy of putative antidiabetic agents from plants. While evidence-based phytotherapy for diabetes is finding its voice in the world again, the use of medicinal plants to manage diabetes is a daunting reality as much as it is a bountiful prospect. There is an urgent need to put the use of herbal remedies and other natural products into the correct medical perspective"
The Int Journal of Molecular Science report "Topical applications of plant oils may have different effect on the skin according to their composition and the pathophysiological context of the skin. The composition varies by different extraction methods. When applied topically, constituents of plant oils (triglycerides, phospholipids, FFAs, phenolic compounds and antioxidants) may act synergistically by several mechanisms: (i) promoting skin barrier homeostasis; (ii) antioxidative activities; (iii) anti-inflammatory properties; (iv) direct and indirect (upregulation of antimicrobial peptides) anti-microbial properties; (v) promoting wound healing; and (vi) anti-carcinogenic properties. Future studies can add to current findings to allow for better understanding of these oils, with the potential to develop dermatological treatments and skin care products using these oils."
The Journal Alternative and Complementary Medicine report "Retrospective database analysis demonstrates the potential that acupressure can be an effective, complementary nonpharmacologic tool for relief pain and anxiety with a high degree of participant satisfaction"
The Journal Atherosclerosis report "In conclusion, our findings from this large Japanese cohort supported a significant inverse association between chocolate consumption and risk of developing stroke in women but not in men. However, residual confounding could not be excluded as an alternative explanation for our findings. Sex-specific analysis may be needed in further studies examining the health effect of chocolate consumption"
The Journal Nutrition Research report "In conclusion, chronic proprietary spearmint extract (PSE) supplementation improved scores in 2 domains of attention: complex and sustained. Benefits were also observed during 2 specific tests: the shifting attention test and the 4-part continuous performance test. The present study is the first time that improved attention has been demonstrated after chronic consumption of PSE in young, healthy individuals and provides further support to the body of evidence indicating that PSE is an efficacious nootropic.
The European Journal of Integrative Medicine report "Osteoarthritis (OA) is one of the most common and fast-growing chronic diseases among older adults. The aim of this study was to assess the effect of acupressure therapy on pain, stiffness, and physical functioning of a knee affected by osteoarthritis......Conclusion Acupressure may be an effective intervention for reducing the pain, stiffness, and improving the function of knees with osteoarthritis."
The Journal Evidence Based Complementary and Alternative Medicine report "In conclusion, in this mouse model of bone cancer pain yokukansan (YKS) significantly lessened cancer pain behavior by suppressing MMP-9 expression, suppressing the expression in bone tissue in the early phase and in the spinal cord in the late phase of pain development.
Yokukansan (YKS) is a Japanese herbal medicine consisting of 7 main galenicals, Atractylodes lancea, Poria sclerotium, Cnidium officinale, Angelica acutiloba, Bupleurum falcatum, Glycyrrhiza uralensis, and Uncaria rhynchophylla
The Journal of Ethnopharmacology report "Conclusion The results of this study provide new scientific evidence for the traditional use of local medicinal plant species C. lansium, L. indica, P. bleo, S. crispus, V. amygdalina and V. trifolia in cancer treatment. These results highlight the importance of the upkeep of these indigenous plants in modern society and their relevance as resources for drug discovery."
The American Journal of Psychiatry report "The results of this double-blind randomized placebo controlled trial indicated that administration of 400 mg or 800 mg of CBD reduced cue-induced craving and anxiety in heroin-abstinent individuals, suggesting a potential role for CBD to alleviate clinical signs and symptoms critical to the continued cycle of addiction. The effects of CBD on drug cue–induced craving and anxiety were evident soon after acute exposure to the drug (session 1). In addition, there was a protracted effect on these measures 1 week after short-term repeated administration of CBD (session 4). CBD also tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels that were induced by salient drug cues. Importantly, CBD administration (at 400 mg or 800 mg) was associated with only mild adverse events"
The Journal Evidence Based Complementary and Alternative Medicine report "Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant therapy in clinical use and has been shown to be effective in cancer patients. However, the mechanism of JDTYS is still unclear. Therefore, the aim of the present study is to investigate the chemopreventive effects of JDTYS for esophageal squamous cell carcinoma (ESCC) and to clarify the potential mechanism.....In summary, we provided evidence that JDTYS significantly inhibits the formation of esophageal precancerous lesions induced by NMBA. The inhibitory effect of JDTYS on esophageal precancerous lesions is related to downregulation of proliferation related proteins Ki67 and c-Jun and modulation inflammation related proteins COX-2, NF-κB, PTX3, and CD11B.
The Journal Phytotherapy Research report "In conclusion, the present study shows that the anxiolytic‐like effect of Citrus sinensis essential oil seems to be mediated by the nitrergic system."
The Journal of the National Cancer Institute report "In summary, we found higher vitamin E status, as measured by serum alpha-tocopherol concentrations from two blood collections taken three years apart, were related in a dosedependent manner to decreased lung cancer incidence during a 28-year period. The inverse association was observed primarily among younger men and those with fewer cumulative years of cigarette smoking. Our findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.
The Journal Evidence Based Complementary and Alternative Medicine report "The results of current experiments indicated that wound healing effects of Callicarpa nudiflora water extract (CNE) were quicker and better than Vaseline and Silver sulfadiazine (SSD) in a deep second-degree scald rat model. Macroscopic difference of wound closure in proliferation and tissue remodeling phase suggested a positive effect of CNE on wound closure after 12 days since scald wound induction. The 20% CNE-treated group exhibited structures of epidermis and dermis were well restored with minimum of scars on the last phase of healing."
The Journal Molecular Psychiatry report "Excess oxidative stress is increasingly appreciated to participate in the pathophysiology of brain disorders, and decreases in the major antioxidant, glutathione (GSH), have been reported in multiple studies.....We found that the naturally occurring isothiocyanate sulforaphane increased blood GSH levels in healthy human subjects following 7 days of daily oral administration. In parallel, we explored the potential influence of sulforaphane on brain GSH levels in the anterior cingulate cortex, hippocampus, and thalamus via 7-T magnetic resonance spectroscopy. A significant positive correlation between blood and thalamic GSH post- and pre-sulforaphane treatment ratios was observed, in addition to a consistent increase in brain GSH levels in response to treatment. This clinical pilot study suggests the value of exploring relationships between peripheral GSH and clinical/neuropsychological measures, as well as the influences sulforaphane has on functional measures that are altered in neuropsychiatric disorders.
* Sulforaphane is a natural phytochemical compound abundant in the seeds and sprouts of cruciferous plants such as broccoli.
The Journal Planta Medica report "In this study, wounds treated with Rosehip Oil (RO) healed rapidly and the period of epithelialization time was shortened when compared to that of the control group. Wounds in the RO group showed lower infiltration of inflammatory cells, enhanced proliferation of fibroblasts, collagenation, angiogenesis, and better collagen remodeling (basket weave meshwork of collagen). These provided strong support for the effective healing activity and scar-improving efficacy of RO
The Journal Evidence Based Complementary and Alternative Medicine report "This study demonstrates that a compound of four Chinese herbs, namely, P. lobata (Willd.), S. miltiorrhiza, S. chinensis, and S. marianum, can be a novel therapeutic agent on preventing and reversing Alcoholic Liver Fibrosis (ALF), and the underlying mechanism of the protective effects may involve TGF-β1/Smad signaling pathway.
The Journal Alternative and Complementary Medicine report "Through the analysis of green tea consumption and Coronary Arterial Disease (CAD) related biomarkers, we concluded that a small amount, high-frequency green tea consumption was associated with a reduced risk of CAD in female populations in Guangzhou, China, and the association might be partly due to altered CAD-related biomarkers.
The Journal of Functional Foods report "These findings are consistent with clinical data indicating that elderberry can mitigate the duration and severity of influenza symptoms in patients. The action of elderberry is both direct – suppressing viral entry, affecting the post-infection phase, and viral transmission from cell to cell, and indirect – by modulating the release of cytokines such as IL-6, IL-8, and TNF. These data support the use of Sambucus nigra berries as nutraceutical ingredients for the management of influenza infection.
The American Botanical Council report "Breast cancer is the most common cancer in the United States, with 266,120 cases in women and 2,550 cases in men diagnosed in 2018.The majority of women diagnosed with breast cancer will undergo conventional treatment in the form of surgery, radiation, chemotherapy, and/or endocrine therapy. Many of these women seek additional integrative therapies, including botanicals, to improve their tolerance to, and the efficacy of, these conventional treatments.
While the clinical data supporting the use of botanicals concurrent with conventional treatment is far from robust, there is a body of emerging data. One area of interest is the reduction of adverse side effects, which can make conventional treatment a more tolerable experience and improve treatment adherence, thereby supporting better outcomes. This article provides an overview of the current state of evidence for selected botanicals for improving outcomes with conventional therapies.
The American Journal of Clinical Nutrition report "In this cohort of eastern Finnish middle-aged and older men, a higher ratio of animal to plant protein in the diet and higher meat intake were related to increased mortality risk. Furthermore, higher total protein intake appeared to be associated with increased mortality risk mainly among those with a disease history at baseline. Apart from meat intake, other protein sources—that is, dairy, fish, egg, and plant protein sources—were not associated with mortality risk."
The European Journal of Integrative Medicine report "The application of rose oil aromatherapy by inhalation reduced the scores of preoperative anxiety of patients undergoing septorhinoplasty/rhinoplasty."
The Journal Evidence Based Complementary and Alternative Medicine report "This review found that Cordyceps sinensis could benefit patients with GOLD stage 2 to 3 COPD in terms of exercise tolerance and life quality. It may have a potential effect on improving lung function. Cordyceps sinensisseemed to be beneficial in reducing exacerbation and improving symptoms in stable COPD of GOLD stages 2 to 3 with few adverse events. But we could not draw strong conclusions on effectiveness or safety due to methodological weaknesses and risk of bias of the included studies."
The Journal Alternative and Complementary Medicine report "The results indicated that a combination of Melissa officinalis plus Nepeta menthoides was effective for the treatment of insomnia. The severity of insomnia, total PSQI, sleep latency, daytime dysfunction, and sleep disturbance indicators all decreased in the treatment group, and the sleep efficacy, sleep quality, and sleep duration were increased.
The Journal Military Medical Research report "Our findings have honed the existing knowledge base on therapeutic horseback riding (THR), a beneficial intervention for veterans with PTSD, by identifying a clinically meaningful dosage of THR. A 3-week THR program was effective, and a 6-week program produced clinically significant outcomes in PTSD levels. Older veterans, such as the majority in our sample, may have been diagnosed with PTSD decades ago; THR may be particularly promising for them. It may be important for health systems to recognize such promise by supporting THR as a reimbursable complementary therapy."
The British Journal of Nutrition report "This dietary intervention study in healthy volunteers identified specific effects of dark chocolate on digestive and cerebral function. These findings add to the body of literature indicating that naturally occurring substances in chocolate, in particular cocoa flavanols, in isolation and in combination, have measurable biological effects. Future research will establish if these are clinically relevant. Acute and chronic disturbances in bowel function are common in the community and can be a major burden....If the “nutraceutical” effects of dark chocolate or cocoa-based products are confirmed, then this could be a safe and popular alternative to pharmacological treatment. If, as expected, there are also positive effects on well-being, then the combination of peripheral and central effects could be a much needed, novel approach for the treatment of participants with conditions such as irritable bowel syndrome that are affected by both disorders of digestive function and mood
The Journal of Psychoactive Drugs report "Results indicated that psilocybin enhanced divergent thinking and emotional empathy the morning after use. Enhancements in convergent thinking, valence-specific emotional empathy, and well-being persisted seven days after use. Sub-acute changes in empathy correlated with changes in well-being. The study demonstrates that a single administration of psilocybin in a social setting may be associated with sub-acute enhancement of creative thinking, empathy, and subjective well-being. Future research should test whether these effects contribute to the therapeutic effects in clinical populations."
The Journal Nutrition Research report "RNA-Seq Expression Profiling analyses from a pilot clinical trial in which women with breast cancer consumed 2 ounces of walnuts per day for 2 to 3 weeks between the diagnostic biopsy and subsequent surgery showed that gene expression in the tumor was modified in ways expected to slow proliferation, reduce inflammation, reduce metastasis and to increase cancer cell death. It seems likely that if gene expression was modified in the tumor due to consumption of walnuts, then gene expression of any metastatic cells should also be modified thus decreasing risk for cancer recurrence."
The Journal Clinical Nutrition report "There is a large body of evidence which supports the role of inflammation in the pathophysiology of mental health disorders, including depression. Dietary patterns have been shown to modulate the inflammatory state, thus highlighting their potential as a therapeutic tool in disorders with an inflammatory basis....These results provide an association between pro-inflammatory diet and risk of depression. Thus, adopting an anti-inflammatory diet may be an effective intervention or preventative means of reducing depression risk and symptoms
The Journal of Child and Adolescent Psychopharmacology report "This study provides evidence for satisfactory outcomes with saffron in treatment of ADHD. In this double-blind randomized trial of C. sativus versus methylphenidate in treatment of ADHD, C. sativus was as effective as methylphenidate. The clinical relevance of these findings was emphasized by improvements seen in both Parent and Teacher Rating Scale scores. Also C. sativus was safe and showed equally or lesser adverse effects.
The Journal Alternative and Complementary Medicine report "This study aimed at identifying areas of consensus among naturopathic experts in IBS. Panelists reached consensus on a 45-item list of reasonable naturopathic approaches for IBS in North America. Consensus was reached in the domains of general approaches to IBS, office visits, tracking progress, testing, interventions, and resources. It is our intention that these results will inform protocol development in future randomized controlled trials. We believe that there is opportunity for future refinement of these consensus guidelines, reflecting an evolving field of evidence-informed practice of naturopathic medicine."
The Journal Complementary and Alternative Medicine report "E-Zhu (Curcuma zedoaria) is known as a classical traditional Chinese medicine and widely used in the treatment of cancers, cardiovascular disease, inflammation, and other diseases. Its main components include curcumol and curcumin, which have anti-inflammatory and antifibrosis effects.
In conclusion, our findings perfectly supported the hypothesis demonstrated that curcumol and curcumin could reduce the expressions of inflammatory factors by inhibiting the NF-κB signaling pathway and TGF-β1/Smads signaling pathway.
The Journal Complementary and Alternative Medicine report " this review included a summary of the data published by many researchers related to the protective and/or treatment role that propolis and/or its active ingredients play against gastrointestinal associated disorders that affect humans. The focus was on the following: oral mucositis, ulcerative colitis, gastrointestinal cancers, and gastric ulcers. Analysis of the published work indicated that the efficacy of propolis in the treatment of gastrointestinal disorders could be attributed to its antioxidants and anti-inflammatory properties.
The Journal Alternative and Complementary and Alternative Medicine report "Despite widespread use, there remains a paucity of research exploring cancer patients’ experiences of receiving complementary therapy treatment. We wanted to gain insight into the experiences of patients using a complementary therapy outpatient service offering aromatherapy, massage, reflexology and Reiki....Qualitative comments collected from this evaluation indicate that complementary therapies can address both physical and emotional concerns often simultaneously and provide a unique therapeutic space for patients. Many patients have not had this experience before and this may introduce them to new methods of addressing complex multi dimensional issues resulting from living with a cancer diagnosis."
The Journal Alternative and Complementary Medicine report "Geriatric depression is a major public health problem in China. The study compared the intervention and follow-up effects of aromatherapy massage and inhalation on symptoms of depression in community-dwelling older adults after an 8-week intervention.
Conclusion: Both aromatherapy massage and aromatherapy inhalation may have important implications for intervening depression in older adults
The Intl Journal. Environ Res. Public Health report "Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. .... The results indicate that the 5% concentration of Cayenne pepper in the preparation of CPC is the best choice, since no additional effects can be obtained with the 10% concentration, and the effects are higher than those observed at the 2.5% concentration. Importantly, 5% CPC application did not induce a significant increase of inflammatory-related biomarkers, suggesting that 20-min application has no negative side effects at systemic levels
The Int. J. Environ. Res. Public Health report "The aim of this study was to examine the relationship between estimated residential exposure to agricultural chemical application and premature mortality from Parkinson’s disease (PD) in Washington State....The relationship between pesticide exposure and premature mortality aligns with previous biological, toxicological, and epidemiological findings. Glyphosate, the world’s most heavily applied herbicide, and an active ingredient in Roundup® and Paraquat, a toxic herbicide, has shown to be associated with the odds of premature mortality from PD.
The University of Illinois at Chicago via NewsWise report "A growing body of evidence supports the idea that alcohol exposure early in life has lasting effects on the brain and increases the risk of psychological problems in adulthood. Now, researchers at the University of Illinois at Chicago have found that adolescent binge drinking, even if discontinued, increases the risk for anxiety later in life due to abnormal epigenetic programming."
The Ramazzini Institute via GMWatch report "Global Glyphosate Study pilot phase shows reproductive and developmental effects at "safe" dose"
A new study has found that exposure to glyphosate-based herbicides (GBHs), including Roundup, caused reproductive and developmental effects in both male and female rats, at a dose level currently considered safe in the US (1.75 mg/kg bw/day). Exposure to GBHs was associated with androgen-like effects, including a statistically significant increase of anogenital distance (AGD) in males and females, delay of first estrus, and increased testosterone in females, in the study conducted by scientists at the Ramazzini Institute, Bologna, Italy.
The Journal Cognitive Behaviour Therapy report "To our knowledge, this is the first meta-analysis to examine the efficacy of Mindfulness Based Cognitive Therapy (MBCT) specifically for patients who are currently experiencing depressive symptoms....Given that MBCT may be of similar efficacy to other active therapies for currently depressed individuals, further research could continue to examine the efficacy of MBCT in other psychiatric conditions (e.g. anxiety disorders).
The European Journal of Integrative Medicine report "Overall, present study suggest that the selected plants such as Cassia occidentalis, Callistemon viminalis, Cleome viscosa and Mimosa hamataexhibited significant cytotoxicity against MCF-7 breast cancer cells along with inhibition of angiogenesis in CAM model and scavenging of free radicals.
The American Academy of Neurology via Newswise report " For people with multiple sclerosis (MS), drinking around 290 calories per day of soda or other sugar-sweetened beverages, or the equivalent of about two cans of non-diet soda, may be tied to more severe symptoms and a higher level of disability compared to people with MS who seldom consume sugar-sweetened beverages, according to a preliminary study."
The Journal Parkinsons Disease report "Aerobic exercise tended to best improve memory in individuals with Parkinsons Disease (PD). Further, exercise in general appears to be associated with improved cognitive function in individuals with PD. However, improvements might be limited to certain cognitive domains (global cognitive function, executive function or memory). Besides cognitive function, exercise, regardless of mode, tended to slow disease progression in individuals with PD
The Journal Molecules report "Obesity is a common but often underrated condition that is globally considered to be a major public health concern that contributes significantly to the rate of morbidity and death. This review has shown the effectiveness of Hibiscus sabdariffa extract (HSE) on obesity-related parameters according to different experimental designs employed in various studies reviewed. Results have consistently reported that HSE consumption reduces body weight, lipid accumulation and total cholesterol metabolism in both animal and human studies. Its effectiveness in inhibiting pancreatic lipase and on adipocyte differentiation has also been frequently reported, thus confirming its therapeutic potential in obesity management. H. sabdariffa extracts are generally considered to have a low degree of toxicity. However, some studies revealed that H. sabdariffa consumption at high doses may have some adverse effects. Hence more animal and clinical studies are required to determine safe doses of H. sabdariffa to balance the therapeutic and toxicological effects
The Iranian Journal of Basic Medical Science report "Chronic neuropathic pain is a common significant and debilitating problem that presents a major challenge to health-care. Despite the large number of available drugs, there are no curative conventional treatments for neuropathic pain. Nowadays, more attention has been focused on the herbal formulation in the field of drug discovery. Therefore, we performed an extensive review about herbal drugs and plants that exhibited protective effects on neuropathic pain... The more common plants which are used for the treatment of neuropathic pain are included as: Acorus calamus, Artemisia dracunculus, Butea monosperma, Citrullus colocynthis, Curcuma longa, Crocus sativus, Elaeagnus angustifolia, Ginkgo biloba, Mitragyna speciosa, Momordica charantia, Nigella sativa, Ocimum sanctum, Phyllanthus amarus, Pterodon pubescens Benth, Rubia cordifolia and Salvia officinalis...
In conclusion, this review suggests that some herbal plants can be suitable candidates for the treatment of neuropathic pain.
The Journal of the American College of Nutrition report "This study evaluated the effect of cinnamon on disease activity, serum levels of some inflammatory markers, and cardiovascular risk factors in women with rheumatoid arthritis (RA)
In conclusion, this study demonstrates the beneficial effect of cinnamon supplement on the improvement of disease activity and inflammatory biomarkers in RA. The findings indicated that the administration of cinnamon at 2000 mg/d for 8 weeks resulted in a significant reduction in serum TNF-a, CRP, tender and swollen joints count, and blood pressure in women with RA. Regarding the availability and lack of side effects, the regular intake of cinnamon supplement may be used as a pharmacological agent in the treatment of RA.
The Journal Chinese Medicine report "Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely Andrographis paniculata, Acanthopanax senticosus, Camellia sinensis, and Hedyotis diffusa were eventually selected to form an innovative herbal formula.
In summary, our innovative Chinese herbal formula was demonstrated to possess anti-tumor, anti-metastatic and bone-protective activities in metastatic breast tumor-bearing mice. The preclinical data generated in this study would lead to the development of evidence-based supplement as adjuvant therapy for metastatic breast cancer.
The Journal Phytherapy Research report "Of the phytomedicines reviewed, P. methysticum (Kava) has the largest evidence base for use in the anxiety disorders, with tripartite level of support from in vitro, in vivo, and human clinical studies. Thus, P. methysticum remains the hallmark anxiolytic phytomedicine (minor concerns over liver toxicity notwithstanding). It is the most strongly evidenced for generalised anxiety, with clinical investigations now examining GABA metabolite changes via neuroimaging, and whether individual gene differences in GABA pathway polymorphisms influence treatment response. V. officinalis, C. asiatica, M. recutita, G. biloba, P. incarnata, and W. somnifera offer the next most extensive evidence for reducing anxiety through GABA‐related pathways; all with preclinical studies of GABA‐ergic action in rodent animal models, with human studies
The Journal Pain report "The present study shows that mindful individuals are less sensitive to pain and exhibit significantly lower activation in the precuneus/dPCC, central nodes of self-referential and nociceptive processing.... These findings could be utilized to better develop adjunctive pain therapies (biofeedback; mindfulness meditation; dialectical behavioral therapy) to specifically target increases in trait mindfulness and reductions in PCC/precuneus activity to treat pain.
Avicenna Journal of Phytomedicine report ":Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice....Administration of crocin reduced d-galactose-induced aging in mice through inhibition of oxidative stress, reduction of inflammation and elevation of sex hormones"
Avicenna Journal of Phytomedicine report "Saffron has beneficial effects on depression and homocysteine level in patients with major depression."
The Journal Cannabis and Cannabinoid Research report "Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, and new therapeutic strategies are still required. Here we screened a synthetic cannabinoid library to identify compounds that uniformly reduce the viability of seven CRC cell lines......We identified three families of cannabinoid compounds that reduce CRC cell viability through a noncanonical receptor mechanism. Future modification of these compounds may lead to the development of novel therapies to treat this disease."
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