Research - Swertia chirata
Antianaemic Potential of Swertia chirata on Phenylhydrazine Induced Reticulocytosis in Rats
Ashish Turaskar1*, Sachin More1, Rizwan Sheikh1, J. Gadhpayle2, Dr. S. L. Bhongade1, Vikas Shende3
1Manoharbhai Patel Institute of Pharmacy [B.Pharm.] Gondia [MS] India
2S. N. Mor College of Science, Tumsar, Bhandara [MS] India
3Sharadchandra Pawar College of Pharmacy, Ottur, Pune, [MS] India
Abstract
The antianemic potential of Swertia chirata extracts on phenylhydrazine induced anemia in rats was investigated. The ethanolic extract of Swertia chirata leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of this plant extracts at 200 mg/kg/day and 400 mg/kg/day, to the rats previously treated with phenylhydrazine, increased the concentration of haemoglobin, red blood cells number, haematocrit and reticulocytes rate.
Conclusion
The extracts of Swertia chirata leaves reversed anaemia induced by phenylhydrazine model of anaemia similar to those induced by parasite such as Plasmodium falciparum17. The vitamin and mineral constituents of the leaf appear most likely as the active ingredients responsible for the haematinic effect of Swertia chirata leaves. This result supports at least partially the traditional use of Swertia chirata in the treatment of anaemia.
Source : American Journal of Phytomedicine and Therapeutics
Link to Full Article
Ashish Turaskar1*, Sachin More1, Rizwan Sheikh1, J. Gadhpayle2, Dr. S. L. Bhongade1, Vikas Shende3
1Manoharbhai Patel Institute of Pharmacy [B.Pharm.] Gondia [MS] India
2S. N. Mor College of Science, Tumsar, Bhandara [MS] India
3Sharadchandra Pawar College of Pharmacy, Ottur, Pune, [MS] India
Abstract
The antianemic potential of Swertia chirata extracts on phenylhydrazine induced anemia in rats was investigated. The ethanolic extract of Swertia chirata leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of this plant extracts at 200 mg/kg/day and 400 mg/kg/day, to the rats previously treated with phenylhydrazine, increased the concentration of haemoglobin, red blood cells number, haematocrit and reticulocytes rate.
Conclusion
The extracts of Swertia chirata leaves reversed anaemia induced by phenylhydrazine model of anaemia similar to those induced by parasite such as Plasmodium falciparum17. The vitamin and mineral constituents of the leaf appear most likely as the active ingredients responsible for the haematinic effect of Swertia chirata leaves. This result supports at least partially the traditional use of Swertia chirata in the treatment of anaemia.
Source : American Journal of Phytomedicine and Therapeutics
Link to Full Article