Research - Sphaeranthus indicus
Efficacy and Tolerability of an Herbal Formulation for Weight Management
Judith S. Stern,1,2 Jan Peerson,1,3 Artatrana T. Mishra,4 Venkata Sadasiva Rao Mathukumalli,5 and Poorna Rajeswari Konda6
1Department of Nutrition, University of California–Davis, Davis, California, USA.
2Department of Internal Medicine, University of California–Davis, Davis, California, USA.
3Program in International and Community Nutrition, University of California–Davis, Davis, California, USA.
4Department of General Medicine, Nagarjuna Hospitals, Vijayawada, India.
5Department of Internal Medicine, Alluri Sitarama Raju Academy of Medical Sciences (ASRAM), Eluru, India.6Suraksha Health Village, Vijayawada, India.
Abstract
The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled,clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40kg/m2. Participants were randomized into two groups receiving either 400mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000kcal/day) throughout the study and walked 5 days a week for 30min. The primary outcome was reduction inbody weight. Secondary outcomes were reduction in BMI and in waist and hip circumference. Serum glycemic, lipid, and adiponectin levels were also measured. Ninety-five subjects completed the trials, and data from these two studies were pooled and analyzed. At study conclusion (8 weeks), statistically significant reductions in body weight (5.2kg;P<.0001), BMI(2.2kg/m2;P<.0001), as well as waist (11.9cm;P<.0001) and hip circumferences (6.3cm;P=.0001) were observed in th eherbal group compared with placebo. An increase in serum adiponectin concentration was also found in the herbal grou pversus placebo (P=.0008) at study conclusion along with reductions in fasting blood glucose (12.2%,P=.01), cholesterol(13.8%,P=.002), and triglyceride (41.6%,P<.0001) concentrations. No changes were seen across organ function panels,multiple vital signs, and no major adverse events were reported. The minor adverse events were equally distributed between the two groups. Our findings suggest that the herbal blend appears to be a well-tolerated and effective ingredient for weight management.
Source : Journal of Medicinal Food
Link to full Article
Judith S. Stern,1,2 Jan Peerson,1,3 Artatrana T. Mishra,4 Venkata Sadasiva Rao Mathukumalli,5 and Poorna Rajeswari Konda6
1Department of Nutrition, University of California–Davis, Davis, California, USA.
2Department of Internal Medicine, University of California–Davis, Davis, California, USA.
3Program in International and Community Nutrition, University of California–Davis, Davis, California, USA.
4Department of General Medicine, Nagarjuna Hospitals, Vijayawada, India.
5Department of Internal Medicine, Alluri Sitarama Raju Academy of Medical Sciences (ASRAM), Eluru, India.6Suraksha Health Village, Vijayawada, India.
Abstract
The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled,clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40kg/m2. Participants were randomized into two groups receiving either 400mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000kcal/day) throughout the study and walked 5 days a week for 30min. The primary outcome was reduction inbody weight. Secondary outcomes were reduction in BMI and in waist and hip circumference. Serum glycemic, lipid, and adiponectin levels were also measured. Ninety-five subjects completed the trials, and data from these two studies were pooled and analyzed. At study conclusion (8 weeks), statistically significant reductions in body weight (5.2kg;P<.0001), BMI(2.2kg/m2;P<.0001), as well as waist (11.9cm;P<.0001) and hip circumferences (6.3cm;P=.0001) were observed in th eherbal group compared with placebo. An increase in serum adiponectin concentration was also found in the herbal grou pversus placebo (P=.0008) at study conclusion along with reductions in fasting blood glucose (12.2%,P=.01), cholesterol(13.8%,P=.002), and triglyceride (41.6%,P<.0001) concentrations. No changes were seen across organ function panels,multiple vital signs, and no major adverse events were reported. The minor adverse events were equally distributed between the two groups. Our findings suggest that the herbal blend appears to be a well-tolerated and effective ingredient for weight management.
Source : Journal of Medicinal Food
Link to full Article