Research - Gout
Effects of RuPeng15 Powder (RPP15) on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats
Y.-Y. Kou,1 Y.-F. Li,1 M. Xu,2,3 W.-Y. Li,2,3 M. Yang,1 and R.-L. Li1
1Pharmacology Department, Medical College, Qinghai University, China
2Pharmacy Department, Qinghai Red Cross Hospital, Xining 810000, China
3Gastroenterology Department, Qinghai Red Cross Hospital, Xining 810000, China
Abstract
RuPeng15 Powder (RPP15) is a herbal multicompound remedy that originates from traditional Tibetan medicine and possesses antigout, anti-inflammatory, and antihyperuricemic properties based on the traditional conceptions. The present study was undertaken to evaluate the therapeutic effect of PRP15 in rat gouty arthritis induced by monosodium urate (MSU) crystals. In the present study, we found that treatment with RPP15 (0.4, 0.8, and 1.2 g/kg) in rats with gouty arthritis induced by MSU crystals significantly attenuated the knee swelling. Histomorphometric and immunohistochemistry analyses revealed that MSU-induced inflammatory cell infiltration and the elevated expressions of nuclear transcription factor-κB p65 (NF-κB p65) in synovial tissues were significantly inhibited, and enzyme-linked immunosorbent assay (ELISA) result showed that MSU-induced high levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-8 (IL-8) in synovial fluid were reduced by treatment with RPP15 (0.4, 0.8, and 1.2 g/kg). We conclude that RPP15 may be a promising candidate for the development of a new treatment for gout and its activity of antigout may be partially related to inhibiting TNF-α, IL-1β, IL-8, and NF-κB p65 expression in the synovial tissues.
Source : Evidence Based Complementary and Alternative Medicine
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The role of Western herbal medicine in the treatment of gout
Nadia Corpa,b,1,Barbara Pendrya,∗
a Medicines Research Group, School of Health and Bioscience, University of East London, Water Lane, Stratford, London, UK
b Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University,Keele, Staffordshire ST55BG, UK
Abstract
Gout has been recognised as a clinically distinct disease for over four millennia. It is one of the most prevalent inflammatory arthropathies and a true crystal deposition disease.Current consensus holds that its management in primary orthodox health care is suboptimal. This study aimed to identify whether herbal medicine offers an effective alternative or complementary approach for managing patients with acute and chronic gout. Three approaches were taken: a survey of medical herbalists to gauge
contemporary approaches;historical and contemporary texts were scrutinised to identify any herbs indicated for gout;and an evidence review to establish the current evidence base for the herbal treatment of gout. While gout was not a frequent presentation in practice, the majority of medical herbalists surveyed had treated it at some point in time.Moreover,most reported herbal medicine had a definite benefit for patients with gout, usually taking effect within one or two months. In general ,the herbs used in clinical practice were mainly chosen for their ability to eliminate uric acid (Apium graveolens, Urtica spp, Taraxacum officinale) or as antiinflammatories (Harpagophytum procumbens,Filipendula ulmaria,Salix spp,Betula spp,Curcumalonga and Guaiacum spp.). There was some agreement in the more popular herbs cited for gout in herbal texts and prescribed by practitioners, and given the lack of scientific evidence identified, suggests herb choice was largely influenced by traditional use.A paucity of evidence was highlighted regarding the effectiveness of Western herbal medicine for gout,a single clinical trial was identified;however,it was of poor quality with unclear or high risks of bias.Given the effectiveness of herbal medicine in treating patients with gout reported by practitioners, together with the lack of a strong evidence-base identified in this study, further research is warranted.Practice-based evidence,such as the systematic collection of clinical treatment outcomes in practice,together with large,well-designed pragmatic clinical trials are required to establish the effectiveness of herbal medicine in the treatment of gout
Source : Journal of Herbal Medicine
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