Research - Tinnitus
Effects of C-phycocyanin and Spirulina on Salicylate-Induced Tinnitus, Expression of NMDA Receptor and Inflammatory Genes
Juen-Haur Hwang, Jin-Cherng Chen, Yin-Ching Chan
Effects of C-phycocyanin (C-PC), the active component of Spirulina platensis water extract on the expressions of N-methyl D-aspartate receptor subunit 2B (NR2B), tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and cyclooxygenase type 2 (COX-2) genes in the cochlea and inferior colliculus (IC) of mice were evaluated after tinnitus was induced by intraperitoneal injection of salicylate. The results showed that 4-day salicylate treatment (unlike 4-day saline treatment) caused a significant increase in NR2B, TNF-α, and IL-1β mRNAs expression in the cochlea and IC. On the other hand, dietary supplementation with C-PC or Spirulina platensis water extract significantly reduced the salicylate-induced tinnitus and down-regulated the mRNAs expression of NR2B, TNF-α, IL-1β mRNAs, and COX-2 genes in the cochlea and IC of mice. The changes of protein expression levels were generally correlated with those of mRNAs expression levels in the IC for above genes.
This experimental study showed that the both of spirulina platensis water extract and its active component (C-PC) could reduce salicylate-induced tinnitus and reduce expression of NR2B, TNF-α, IL-1β, and COX-2 genes in the cochlea and IC....Therefore, we suggested that the beneficial effects of spirulina or C-PC on tinnitus mainly via inhibiting mRNA expression of NR2B, TNF-α, IL-1β, and/or COX-2 genes.....
Source : PLOSone
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